{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:33:23Z","timestamp":1778776403255,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T00:00:00Z","timestamp":1317945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Our blood bank prepares, on indication or request, a volume\u2010reduced (VR) platelet (PLT) product with greater than 95% reduced plasma content and a 15\u2010fold higher PLT concentration, potentially minimizing adverse reactions due to plasma, in particular for human leukocyte antigen (HLA)\/human PLT antigen (HPA)\u2010matched PLTs when minor ABO incompatibility cannot be avoided. Here we compared the clinical effectiveness of VR apheresis PLTs (APs) with standard APs.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> We performed a single\u2010center cohort study among consecutive alloimmunized patients who received either HLA\/HPA\u2010matched standard APs and\/or VR\u2010APs between 1994 and 2008. The endpoints were corrected count increments (CCIs), time to next transfusion, and frequency of adverse reactions. The CCI of VR PLTs was calculated using the PLT dose before volume reduction. Using a random effects model, 851 transfusions to 68 patients were evaluated for CCI and 731 transfusions to 64 patients for time to next transfusion. The frequency of reported adverse reactions was compared between the groups.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> The 1\u2010hour CCI was 23% (95% confidence interval [CI], 9%\u201042%; p\u2003&lt;\u20030.001) lower and the 24\u2010hour CCI was 17% (95% CI, \u221211% to 59%; p\u2003=\u20030.278) lower after VR\u2010APs. The mean time to next transfusion was similar: standard APs, 3.1 days (95% CI, 2.7\u20103.5); and VR\u2010APs, 2.8 days (95% CI, 2.5\u20103.2). Eight adverse reactions were reported: 4 of 619 in the standard AP group and 4 of 1202 in the VR\u2010AP group.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> VR\u2010APs showed lower 1\u2010 and 24\u2010hour CCIs than standard\u2010APs, which can be largely explained by the lower PLT dose of VR\u2010APs. The benefits of plasma reduction should seriously be outweighed given these lower increments.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03364.x","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T20:36:52Z","timestamp":1318019812000},"page":"742-751","source":"Crossref","is-referenced-by-count":16,"title":["A comparison of volume\u2010reduced versus standard HLA\/HPA\u2013matched apheresis platelets in alloimmunized adult patients"],"prefix":"10.1111","volume":"52","author":[{"given":"\u00c1ine","family":"Honohan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Tomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"van der Bom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"de 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