{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:07:56Z","timestamp":1788343676882,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Due to the fact that the ABO and D system is inherited independently from the HLA system, approximately 40% of allogeneic hematopoietic stem cell transplants (HSCT) are performed across the blood group barrier. Reports on the development of de novo anti\u2010D in patients undergoing reduced\u2010intensity conditioning (RIC) followed by D\u2010mismatched allogeneic HSCT are rare. The objective of this study was to evaluate the frequency of anti\u2010D alloimmunization after D\u2010mismatched HSCT following RIC and its prognostic impact on transplant outcome.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Forty patients with hematologic diseases who underwent D\u2010mismatched HSCT were retrospectively analyzed: 19 D\u2212 patients with a D+ donor and 21 D+ patients with a D\u2212 donor. Routine serologic testing for blood group typing and antibody screening was performed by a column agglutination method every time when transfusion of red blood cell units was requested and in the posttransplantation course to demonstrate establishment of donor ABO type and to detect alloimmunization.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> After a median serologic follow\u2010up of 21 (range, 0 to 73) months after HSCT, anti\u2010D was identified in 2 of 21 (10%) D+ patients receiving a D\u2212 transplant, 23 and 34 months after HSCT. None of the 19 D\u2212 patients with a D+ donor developed an anti\u2010D.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> We observed an infrequent de novo anti\u2010D formation that is more likely in D+ recipients of D\u2212 grafts. However, the development of anti\u2010D does not normally impair the transplant outcome and is not of clinical relevance in the posttransplant course.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03457.x","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T17:34:30Z","timestamp":1322847270000},"page":"1348-1353","source":"Crossref","is-referenced-by-count":13,"title":["Frequency and prognostic value of D alloantibodies after D\u2010mismatched allogeneic hematopoietic stem cell transplantation after reduced\u2010intensity conditioning"],"prefix":"10.1111","volume":"52","author":[{"given":"Nina","family":"Worel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Rabitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda","family":"Leitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Mitterbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kalhs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang R.","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildegard T.","family":"Greinix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198803000-00005"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198204000-00017"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39299154733.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00465.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1182\/blood.V75.1.290.290","article-title":"Pure red cell aplasia of long duration complicating major ABO\u2010incompatible bone marrow transplantation","volume":"75","author":"Gmur JP","year":"1990","journal-title":"Blood"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40050543.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02587.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00209.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1974.tb50783.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01700.x"},{"key":"e_1_2_8_12_2","unstructured":"MollisonPL EngelfrietCP ContrerasM.Blood transfusion in clinical medicine.10thed. 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