{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:33:37Z","timestamp":1787776417807,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> AnWj is a high\u2010prevalence red blood cell (RBC) antigen in the ISBT 901 series. Only nine reports of anti\u2010AnWj have been published since it was first documented in 1972; two of these cases involved transfusion reactions. We present a case of a patient with aplastic anemia who developed anti\u2010AnWj with clinically significant hemolysis after transfusion of AnWj\u2010positive RBCs.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> A 56\u2010year\u2010old woman with aplastic anemia developed a pan\u2010reactive antibody with clinically significant hemolysis after transfusion of RBCs. Investigations included antibody identification by serologic methods at the national immunohematology reference laboratory and the in vitro monocyte\u2010monolayer assay (MMA) to predict clinical significance.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> The antibody was identified as having specificity for the AnWj antigen. The posttransfusion MMA indicated that the antibody had complement\u2010fixing capability highly likely to cause clinically significant acute hemolytic transfusion reactions. The patient required long\u2010term transfusion support with AnWj\u2010negative RBCs and Lu(a\u2212b\u2212) RBCs of the In(Lu) type which have reduced AnWj expression. Cross\u2010Canada and international collaboration was required to obtain rare units for transfusion.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> A case of acute hemolytic transfusion reaction caused by anti\u2010AnWj is reported in a patient with aplastic anemia requiring allogeneic stem cell transplantation. This is the second documented case of anti\u2010AnWj to cause a hemolytic transfusion reaction. The case demonstrates the complexity of managing patients with rare antibodies and the importance of international collaboration in the management of these difficult cases.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03477.x","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T03:25:13Z","timestamp":1326252313000},"page":"1476-1481","source":"Crossref","is-referenced-by-count":17,"title":["Anti\u2010AnWj causing acute hemolytic transfusion reactions in a patient with aplastic anemia"],"prefix":"10.1111","volume":"52","author":[{"given":"Zhaodong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Duffett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Tokessy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Cote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elianna","family":"Saidenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,10]]},"reference":[{"key":"e_1_2_9_2_2","volume-title":"The blood group antigen facts book","author":"Reid ME","year":"2004"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1983.23283172849.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.1991.tb00040.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1986.26186124014.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1986.tb04889.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1992.tb05111.x"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.331094054624.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.21307\/immunohematology-2019-320","article-title":"Red blood cell transfusion in a patient with anti\u2010AnWj: a case report","volume":"23","author":"Stowers RE","year":"2007","journal-title":"Immunohematology"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0124-1"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01216.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00565.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-145672"},{"key":"e_1_2_9_14_2","first-page":"82","article-title":"Evaluation of reticuloendothelial function in autoimmune hemolytic anemia using an in vitro assay of monocyte\u2010macrophage interaction with erythrocytes","volume":"11","author":"Gallager MT","year":"1983","journal-title":"Exp Hematol"},{"key":"e_1_2_9_15_2","first-page":"91","volume-title":"Clinical and serological aspects of transfusion reactions","author":"Garratty G","year":"1983"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07054.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-009-8157-y"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703537"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-010777"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3409"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2011.03477.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2011.03477.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T17:37:42Z","timestamp":1697305062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2011.03477.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,10]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1537-2995.2011.03477.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2011.03477.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,10]]}}}