{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:51:33Z","timestamp":1789977093555,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T00:00:00Z","timestamp":1326412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Thrombotic thrombocytopenic purpura (TTP), a thrombotic microangiopathy, is a clinical diagnosis, characterized by microangiopathic hemolytic anemia and thrombocytopenia without another likely explanation. Some initiators of the disease are well represented in the literature, such as certain drugs, malignancies, and viral illness; however, there are less objective factors still being investigated, with references to hormonal, stress, and seasonal variations considered anecdotally. A better insight of these factors would aid in understanding the pathophysiology of the disease.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> We performed a retrospective review of all idiopathic TTP cases treated with therapeutic plasma exchange at our institution from 1999 to 2008 to determine whether there was seasonal variation in TTP presentation. Seasons were defined as follows: winter\u2003=\u2003December to February; spring\u2003=\u2003March to May; summer\u2003=\u2003June to August; and fall\u2003=\u2003September to November. With the use of Poisson regression models, the incidence between seasons was compared.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> During this study period, a total of 97 cases were recorded. Summer had the highest occurrence of TTP (35%). This was significant compared to the fall (p\u2003=\u20030.012) and the winter (p\u2003=\u20030.019). There were more cases in the summer compared to the spring, but this was not significant.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> In our population, there was a significant difference in the number of TTP cases presenting in summer compared to fall and winter. This supports a possible environmental, infectious, or physiologic influence associated with the summer.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03481.x","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T14:34:04Z","timestamp":1326465244000},"page":"1530-1534","source":"Crossref","is-referenced-by-count":13,"title":["Seasonal association of thrombotic thrombocytopenic purpura"],"prefix":"10.1111","volume":"52","author":[{"given":"Yara A.","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Poisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"McBee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araba","family":"Afenyi\u2010Annan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.154311"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20176"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01436.x"},{"key":"e_1_2_7_5_2","first-page":"28A","article-title":"A prospective case\u2010control study of incident TTP: preliminary results of risk factors for development of the TTP\/HUS syndrome","volume":"46","author":"Bandarenko N","year":"2006","journal-title":"Transfusion"},{"key":"e_1_2_7_6_2","first-page":"51","article-title":"Risk factors for thrombotic thrombocytopenic purpura: results of the surveillance, epidemiology, and risk factors for TTP (SERF\u2010TTP) group","volume":"22","author":"Zakarija A","year":"2007","journal-title":"J Clin Apheresis"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0193"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392202"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.50.1.355"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/319269"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71144-2"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02934718"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05420.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1676-4"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20114"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPGM0SC6KOTCAN"},{"key":"e_1_2_7_17_2","first-page":"56","article-title":"Exacerbations of thrombotic thrombocytopenic purpura\u2010hemolytic uremic syndrome predict infection","volume":"22","author":"Park YA","year":"2007","journal-title":"J Clin Apher"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10260"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.584532"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.010339"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4165"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2011.03481.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2011.03481.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T17:37:00Z","timestamp":1697305020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2011.03481.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,13]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1537-2995.2011.03481.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2011.03481.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,13]]}}}