{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:49:51Z","timestamp":1765381791683},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Extramedullary hematopoiesis (EH) is a compensatory phenomenon that results in the production of blood cell precursors outside the marrow in patients with chronic hemolytic anemia and ineffective erythropoiesis. EH usually involves the liver, spleen, and lymph nodes. It can also be found at paravertebral, intrathoracic, or pelvic locations. Intracranial EH is a rare entity and often asymptomatic but can sometimes lead to symptomatic tumor\u2010like masses. Treatment options are controversial and include hypertransfusion, surgical excision, radiotherapy, and hydroxyurea (HU).<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Successful treatment of an intracranial EH mass with HU and blood transfusions in a beta\u2010thalassemia major patient was discussed along with a review of the published literature on intracranial EH in thalassemia.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> In our patient, the extramedullary hematopoietic mass in the interhemispheric fissure showed a marked improvement after 6 months of HU and hypertransfusion therapy. In the English literature, there are a few cases with intracranial EH and thalassemia, which were treated with different treatment modalities, with different outcomes.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> There is no standard treatment approach in patients with symptomatic EH. HU with hypertransfusion regimen is a reasonable first\u2010choice modality in treating intracranial EH masses.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03499.x","type":"journal-article","created":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T04:13:08Z","timestamp":1325736788000},"page":"1715-1720","source":"Crossref","is-referenced-by-count":19,"title":["Intracranial extramedullary hematopoiesis in patients with thalassemia: a case report and review of the literature"],"prefix":"10.1111","volume":"52","author":[{"given":"Ahmet Emre","family":"Eskazan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhlis 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