{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:52:41Z","timestamp":1789750361749,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T00:00:00Z","timestamp":1331510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> The use of crossmatch\u2010compatible platelets (PLTs) improves posttransfusion corrected count increments (CCIs) in patients with alloimmune PLT refractoriness. However, few reports address the efficacy of utilizing this strategy for patients requiring intensive PLT transfusion therapy lasting several weeks to months.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Medical records of patients with two or more PLT crossmatch assays performed between 2002 and 2010 were reviewed. All patients were refractory to random single\u2010donor apheresis PLT units, defined as two consecutive 1\u2010hour posttransfusion CCIs of less than 7500. A commercial solid\u2010phase adherence assay was used for crossmatching.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Seventy\u2010one patients were included. A median of four crossmatch assays were performed per patient (range, 2\u201017). Mean percent reactivity in initial (58.6%) versus last (55.3%) crossmatch assay for each patient demonstrated no trend toward progressive alloimmunization (p\u2003=\u2003NS). A total of 738 crossmatched PLT units were administered with a mean\u2003\u00b1\u2003standard deviation CCI of 7000\u2003\u00b1\u20037900 (n\u2003=\u2003443 units with adequate 1\u2010hr posttransfusion counts), a significant improvement over random PLTs (p\u2003&lt;\u20030.001). Patients with an initial crossmatch reactivity of greater than 66% were significantly more likely to demonstrate at least one panreactive crossmatch assay, impacting the availability of compatible PLTs for optimum transfusion support. One patient (1.4%) developed WHO Grade IV bleeding.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> Progressive alloimmunization to mismatched antigens does not impact medium\u2010term transfusion support with crossmatched PLTs. Increased reactivity in the initial crossmatch assay can serve as a trigger to initiate workup for HLA\u2010matched PLTs as a second\u2010line approach. However, for most patients, medium\u2010term transfusion support with crossmatched PLTs offers an effective and rapid first\u2010line approach to management of PLT transfusion refractoriness.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2012.03593.x","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T04:27:47Z","timestamp":1331526467000},"page":"2146-2154","source":"Crossref","is-referenced-by-count":27,"title":["Longitudinal management with crossmatch\u2010compatible platelets for refractory patients: alloimmunization, response to transfusion, and clinical outcomes (CME)"],"prefix":"10.1111","volume":"52","author":[{"given":"Arun P.","family":"Wiita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Nambiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07189.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-0409-MOPRTP"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2724"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.12.3428.3428"},{"key":"e_1_2_8_6_2","first-page":"247","article-title":"A mini\u2010review on platelet refractoriness","volume":"90","author":"Rebulla P","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_8_7_2","volume-title":"Wintrobe's clinical hematology","author":"Greer JP","year":"2009"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(00)80007-3"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32792391036.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781444303513"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4080"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01516.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02703.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29389162723.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/90.1.63"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37697335157.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40121446.x"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30490273438.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03181.x"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.5.1519"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.5.1402.1402"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372601"},{"key":"e_1_2_8_24_2","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1182\/blood.V70.6.1727.1727","article-title":"Serial measurement of lymphocytotoxic antibody and response to nonmatched platelet transfusions in alloimmunized patients","volume":"70","author":"Lee EJ","year":"1987","journal-title":"Blood"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb02344.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34394196618.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.1.23.23"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2012.03593.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2012.03593.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:21:42Z","timestamp":1697246502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2012.03593.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,12]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1537-2995.2012.03593.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2012.03593.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,12]]}}}