{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:58:28Z","timestamp":1777348708008,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T00:00:00Z","timestamp":1331510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Monitoring of patients' vital sign values (VSVs) during hemotherapy may have an important role in the recognition and mitigation of transfusion\u2010associated circulatory overload (TACO). Knowledge regarding VSVs and other patient characteristics in bedside\u2010reported TACO or fluid challenge\u2013suspected transfusion reactions (TACO\/FC\u2010STRs) is limited.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> We performed a retrospective observational cohort study of cases of uncomplicated red blood cell (RBC) transfusions (UCTs) and reported suspected transfusion reaction (STR) cases investigated by our hospital's transfusion medicine service (TMS) from January 1, 2005, to February 29, 2008, using data obtained from TMS consult reports and quality improvement databases examining VSVs and patient characteristics in TACO\/FC\u2010STRs.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> The frequency of TACO\/FC\u2010STRs was 0.19% per all RBC units transfused (1:530 units transfused). Both clinically and statistically (p\u2003\u2264\u20030.05) significant changes were encountered in all VSVs in patients experiencing TACO\/FC\u2010STRs either at the 15\u2010minute time interval or at the end\u2010of\u2010transfusion time points. Measured and derived VSVs related to the patients' blood pressure in the peritransfusion period were consistently increased. Approximately two\u2010thirds of TACO\/FC\u2010STR patients also exhibited inflammatory related signs and symptoms at STR bedside presentation. Differences (all p\u2003\u2264\u20030.050) between UCT and TACO\/FC\u2010STR cohorts were seen for patient mean weights (80\u2003kg vs. 72\u2003kg), mean minutes to transfusion completion (121\u2003min vs. 83\u2003min), and mean storage age of suspected sentinel RBC unit (22.5 days vs. 25.2 days).<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> Trend monitoring of peritransfusion VSVs, especially blood pressures, may aid in the bedside recognition of TACO\/FC\u2010STRs. A subset of these patients may also present with febrile and\/or inflammatory signs and symptoms.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2012.03595.x","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T04:28:43Z","timestamp":1331526523000},"page":"2310-2320","source":"Crossref","is-referenced-by-count":53,"title":["Hemotherapy bedside biovigilance involving vital sign values and characteristics of patients with suspected transfusion reactions associated with fluid challenges: can some cases of transfusion\u2010associated circulatory overload have proinflammatory aspects?"],"prefix":"10.1111","volume":"52","author":[{"suffix":"Jr.","given":"Chester","family":"Andrzejewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Popovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa 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