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Clinical and laboratory investigations of the patients suffering reactions after infusion of fresh\u2010frozen plasma (FFP) define the etiology and pathogenesis of the panoply of adverse effects. We review here the pathogenesis, diagnosis, and management of the risks associated with plasma transfusion. Risks commonly associated with FFP include: 1) transfusion\u2010related acute lung injury, 2) transfusion\u2010associated circulatory overload, and 3) allergic and\/or anaphylactic reactions. Other less common risks include 1) transmission of infections, 2) febrile nonhemolytic transfusion reactions, 3) red blood cell alloimmunization, and 4) hemolytic transfusion reactions. The effects of pathogen inactivation or reduction methods on these risks are also discussed. Fortunately, a majority of the adverse effects are not lethal and are adequately treated in clinical practice.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2012.03663.x","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T17:09:43Z","timestamp":1336756183000},"source":"Crossref","is-referenced-by-count":255,"title":["Adverse effects of plasma transfusion"],"prefix":"10.1111","volume":"52","author":[{"given":"Suchitra","family":"Pandey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish N.","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,11]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.00427.x"},{"key":"e_1_2_8_3_2","unstructured":"US Department of Health and Human Services. 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