{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:59:51Z","timestamp":1761418791083},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T00:00:00Z","timestamp":1336003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Other studies have reported high rates of depression and anxiety among human T\u2010lymphotropic virus Type I (HTLV\u2010I)\u2010infected subjects and have even suggested that HTLV\u2010I causes psychiatric disease.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> We interviewed HTLV\u2010I, HTLV\u2010II, and demographically similar HTLV\u2010seronegative blood donors with the Mini\u2010International Neuropsychiatric Interview. Prevalences of major depression and generalized anxiety disorder in each group were calculated and compared to published US population data. Adjusted odds ratios (aOR) and 95% confidence intervals (CIs) controlling for educational achievement, alcohol intake, and self\u2010reported health status were calculated with multivariate logistic regression.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Major depression was diagnosed in five (5.4%) of 93 HTLV\u2010I\u2013positive subjects (aOR, 2.19; 95% CI, 0.63\u20107.55) and 17 (6.6%) of 256 HTLV\u2010II\u2013positive subjects (aOR, 1.61; 95% CI, 0.66\u20103.927), compared to 12 (2.1%) of 585 HTLV\u2010seronegative blood donors. The prevalence of major depression among infected subjects was comparable to the 6.7% prevalence in the US general population. Generalized anxiety disorder was diagnosed in five (5.4%) HTLV\u2010I\u2013positive subjects (OR, 2.32; 95% CI, 0.74\u20107.26) and 12 (4.7%) HTLV\u2010II\u2013positive subjects (OR, 1.65; 95% CI, 0.68\u20104.01), compared to 15 (2.6%) seronegative subjects and 3.1% in the US general population.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> Major depression and generalized anxiety disorder were not significantly more prevalent among HTLV\u2010I\u2013 and HTLV\u2010II\u2013infected former blood donors after controlling for health status and other confounding variables. HTLV\u2010seronegative blood donors had lower prevalences of these conditions than the US population, probably due to a \u201chealthy blood donor effect.\u201d<\/jats:p>","DOI":"10.1111\/j.1537-2995.2012.03677.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T23:16:19Z","timestamp":1336086979000},"page":"60-68","source":"Crossref","is-referenced-by-count":17,"title":["Major depression and generalized anxiety disorder among human T\u2010lymphotropic virus Types I\u2013 and II\u2013infected former blood donors"],"prefix":"10.1111","volume":"53","author":[{"given":"Anne 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