{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:17:37Z","timestamp":1697343457013},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T00:00:00Z","timestamp":1336348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Lipids and other biologically active substances accumulate in platelet concentrates (PCs) during storage. Some of these substances have been suggested to modulate immune responses and to play a pathogenic role in the development of transfusion\u2010related acute lung injury. This study compared the content and impact of some biological response modifiers in PCs treated with pathogen reduction (PR) technology and nontreated PCs.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Apheresis PCs (n\u2003=\u200312) were split in two: one split was subjected to PR treatment (INTERCEPT, Cerus Corp.) and the other split was left untreated. Basic characterization and content of vascular endothelial growth factor (VEGF) and sCD154 were measured. Lipopolysaccharide (LPS)\u2010induced secretion of interleukin\u201010 (IL\u201010) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) was measured after incubation of heparinized whole blood with platelet (PLT) supernatants. The supernatants' neutrophil (PMN)\u2010priming capacity, and thereby activation of the NADPH oxidase, was measured as the rate of superoxide anion production after formyl\u2010Met\u2010Leu\u2010Phe activation. Lipids were extracted from the supernatants on Day 6 and tested for PMN\u2010priming activity.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Supernatants from PR\u2010treated PCs demonstrated significantly higher mean PLT volume (MPV) and O<jats:sub>2<\/jats:sub>, lower pH, CO<jats:sub>2<\/jats:sub>, and HCO<jats:sup>3\u2212<\/jats:sup>, and significantly less LPS\u2010induced TNF\u2010\u03b1 secretion compared to untreated PCs. No differences in swirling, PLT count, potassium levels, glucose consumption, lactate production, IL\u201010, VEGF, sCD154, or PMN\u2010priming activity were found between the groups over time.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> INTERCEPT PR treatment caused no substantial differences in PCs, except for minor changes in MPV and metabolic variables. Further studies are needed to explain the differences in the LPS\u2010induced TNF\u2010\u03b1 secretion.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2012.03681.x","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T06:27:31Z","timestamp":1336458451000},"page":"147-155","source":"Crossref","is-referenced-by-count":8,"title":["Biological response modifiers in photochemically pathogen\u2010reduced versus untreated apheresis platelet concentrates"],"prefix":"10.1111","volume":"53","author":[{"given":"Annette","family":"Vetlesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Mirlashari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7i\u011fdem Akal\u0131n","family":"Akk\u00f6k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marguerite R.","family":"Kelher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samina Y.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Silliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kjeldsen\u2010Kragh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,7]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1992.tb02500.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199911000-00012"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00869.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/10245330512331390447"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36296181925.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-017251"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2005.11.001"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00979.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02412.x"},{"key":"e_1_2_8_11_2","unstructured":"FDA.Fatalities reported to FDA following blood collection and transfusion: annual summary for fiscal year 2010.2011. 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