{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:23:56Z","timestamp":1789025036608,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neonates with <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>hesus c (<jats:styled-content style=\"fixed-case\">Rh\u2009c<\/jats:styled-content>) hemolytic disease of the fetus and newborn (<jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>) are often managed in the same way as neonates with <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>hesus <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">Rh\u2009D<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>, although evidence to support this policy is limited. The objective of this study was to evaluate neonatal outcome in severe <jats:styled-content style=\"fixed-case\">Rh\u2009c HDFN<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">Rh\u2009D HDFN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A retrospective study of (near\u2010)term neonates with severe <jats:styled-content style=\"fixed-case\">Rh\u2009c<\/jats:styled-content> (n\u2009=\u200922) and <jats:styled-content style=\"fixed-case\">Rh\u2009D HDFN<\/jats:styled-content> (n\u2009=\u2009103; without additional antibodies) admitted to the <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eiden <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2000 and <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ctober 2011 was conducted. The need for intrauterine transfusions (<jats:styled-content style=\"fixed-case\">IUTs<\/jats:styled-content>), phototherapy, exchange transfusions (<jats:styled-content style=\"fixed-case\">ETs<\/jats:styled-content>), and top\u2010up transfusions up to 3\u2009months of age were recorded and compared between both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although there was a trend for a slightly more severe antenatal course for <jats:styled-content style=\"fixed-case\">Rh\u2009D HDFN<\/jats:styled-content> reflected by an earlier need for and higher number of <jats:styled-content style=\"fixed-case\">IUT<\/jats:styled-content>s (median [interquartile range], 2 [1.5\u20104] vs. 2 [1\u20102] in <jats:styled-content style=\"fixed-case\">Rh\u2009c HDFN<\/jats:styled-content>; p\u2009=\u20090.070), no significant differences were found for the postnatal course between <jats:styled-content style=\"fixed-case\">Rh\u2009c<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">Rh\u2009D<\/jats:styled-content> group in days of phototherapy (mean, Days 4.8 and 4.6, respectively; p\u2009=\u20090.569), need for <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> (50% vs. 44%, respectively; p\u2009=\u20090.589), and top\u2010up transfusions (62% vs. 78%, respectively; p\u2009=\u20090.128).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Postnatal outcome in neonates with severe <jats:styled-content style=\"fixed-case\">Rh\u2009c HDFN<\/jats:styled-content> is similar compared to neonates with severe <jats:styled-content style=\"fixed-case\">Rh\u2009D<\/jats:styled-content> hemolytic disease in terms of days of phototherapy, need for <jats:styled-content style=\"fixed-case\">ET,<\/jats:styled-content> and need for top\u2010up transfusions. These results justify a similar postnatal management of neonates with <jats:styled-content style=\"fixed-case\">Rh\u2009D<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">Rh\u2009c HDFN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1537-2995.2012.03937.x","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T05:06:34Z","timestamp":1351746394000},"page":"1580-1585","source":"Crossref","is-referenced-by-count":20,"title":["Postnatal outcome in neonates with severe <scp>R<\/scp>hesus <scp>c<\/scp> compared to <scp>R<\/scp>hesus <scp>D<\/scp> hemolytic disease"],"prefix":"10.1111","volume":"53","author":[{"given":"Mirjam E.A.","family":"Rath","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Division of Fetal Medicine, Department of Obstetrics Sanquin Blood Bank, Southwest Region and Department of Immuno\u2010Hematology and Blood Transfusion Leiden University Medical Center  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Division of Fetal Medicine, Department of Obstetrics Sanquin Blood Bank, Southwest Region and Department of Immuno\u2010Hematology and Blood Transfusion Leiden University Medical Center  Leiden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke","family":"Brand","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Division of Fetal Medicine, Department of Obstetrics Sanquin Blood Bank, Southwest Region and Department of Immuno\u2010Hematology and Blood Transfusion Leiden University Medical Center  Leiden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge L.","family":"van Kamp","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Division of Fetal Medicine, Department of Obstetrics Sanquin Blood Bank, Southwest Region and Department of Immuno\u2010Hematology and Blood Transfusion Leiden University Medical Center  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