{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:36:38Z","timestamp":1790228198983,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":6521,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1111\/j.1538-7836.2004.01082.x","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T05:40:54Z","timestamp":1106631654000},"page":"361-368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Expression and subcellular localization of WAVE isoforms in the megakaryocyte\/platelet lineage"],"prefix":"10.1016","volume":"3","author":[{"given":"H.","family":"KASHIWAGI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"SHIRAGA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"KATO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"HONDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"SAKO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"KURATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"KANAKURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"TOMIYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0010","series-title":"Platelets in Thrombotic and Non\u2010Thrombotic Disorders.","first-page":"93","article-title":"Dynamics of the platelet cytoskeleton","author":"Barkalow","year":"2002"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0092-8674(95)90370-4","article-title":"Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia","volume":"81","author":"Nobes","year":"1995","journal-title":"Cell"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0020","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1242\/jcs.114.10.1801","article-title":"WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement","volume":"114","author":"Takenawa","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1034\/j.1600-065X.2000.17808.x","article-title":"Wiskott\u2013Aldrich syndrome protein and platelets","volume":"178","author":"Oda","year":"2000","journal-title":"Immunol Rev"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0030","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1182\/blood.V94.12.4166","article-title":"Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI","volume":"94","author":"Gross","year":"1999","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0035","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1093\/emboj\/17.23.6932","article-title":"WAVE, a novel WASP\u2010family protein involved in actin reorganization induced by Rac","volume":"17","author":"Miki","year":"1998","journal-title":"EMBO J"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0040","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1083\/jcb.142.5.1325","article-title":"SCAR, a WASP\u2010related protein, isolated as a suppressor of receptor defects in late Dictyostelium development","volume":"142","author":"Bear","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0045","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/bbrc.1999.0894","article-title":"Identification of two human WAVE\/SCAR homologues as general actin regulatory molecules which associate with the Arp2\/3 complex","volume":"260","author":"Suetsugu","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0050","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35047107","article-title":"IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling","volume":"408","author":"Miki","year":"2000","journal-title":"Nature"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0055","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nature00859","article-title":"Mechanism of regulation of WAVE1\u2010induced actine nucleation by Rac1 and Nck","volume":"418","author":"Eden","year":"2002","journal-title":"Nature"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0060","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/ncb886","article-title":"The WRP component of the WAVE\u20101 complex attenuates Rac\u2010mediated signaling","volume":"4","author":"Soderling","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0065","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1182\/blood.V100.6.2113","article-title":"Normal Arp2\/3 complex activation in platelets lacking WASp","volume":"100","author":"Falet","year":"2002","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0070","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1182\/blood.V95.4.1283.004k44_1283_1292","article-title":"Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells","volume":"95","author":"Rengan","year":"2000","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0075","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1182\/blood.V98.10.2988","article-title":"WASP and N\u2010WASP in human platelets differ in sensitivity to protease calpain","volume":"98","author":"Shcherbina","year":"2001","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0080","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1083\/jcb.146.6.1319","article-title":"Activation of the CDC42 effector N\u2010WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2\/3 complex and bacterial actin\u2010based motility","volume":"146","author":"Egile","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1538-7836.2003.00529.x","article-title":"Activation of integrin \u03b1IIb\u03b23 in the glycoprotein Ib\u2010high population of a megakaryocytic cell line, CMK, by inside\u2010out signaling","volume":"2","author":"Kashiwagi","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0090","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1182\/blood.V92.10.3710","article-title":"Involvement of Na+\/Ca2+ exchanger in inside\u2010out signaling through the platelet integrin \u03b1IIb\u03b23","volume":"92","author":"Shiraga","year":"1998","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0095","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1182\/blood.V74.1.42.42","article-title":"Growth and differentiation of a human megakaryoblastic cell line, CMK","volume":"74","author":"Komatsu","year":"1989","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0100","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1083\/jcb.147.7.1419","article-title":"Primary megakaryocytes reveal a role for transcription factor NF\u2010E2 in integrin \u03b1IIb\u03b23 signaling","volume":"147","author":"Shiraga","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0105","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI117749","article-title":"Molecular basis of CD36 deficiency. Evidence that a 478C\u2192T substitution (proline90\u2192serine) in CD36 cDNA accounts for CD36 deficiency","volume":"95","author":"Kashiwagi","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0110","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1083\/jcb.137.6.1433","article-title":"Affinity modulation of platelet integrin \u03b1IIb\u03b23 by \u03b23\u2010endonexin, a selective binding partner of the \u03b23 integrin cytoplasmic tail","volume":"137","author":"Kashiwagi","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0115","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1182\/blood.V93.8.2559","article-title":"A mutation in the extracellular cysteine\u2010rich repeat region of the \u03b23 subunit activates integrins \u03b1IIb\u03b23 and \u03b1V\u03b23","volume":"93","author":"Kashiwagi","year":"1999","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0120","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1074\/jbc.271.12.7004","article-title":"The platelet cytoskeleton stabilizes the interaction between \u03b1IIb\u03b23 and its ligand and induces selective movements of ligand\u2010occupied integrin","volume":"271","author":"Fox","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0125","doi-asserted-by":"crossref","first-page":"27605","DOI":"10.1074\/jbc.274.39.27605","article-title":"Phosphorylation of WAVE downstream of mitogen\u2010activated protein kinase signaling","volume":"274","author":"Miki","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0130","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-1759(01)00549-X","article-title":"Flow cytometric determination of intracytoplasmic Wiskott\u2013Aldrich syndrome protein in peripheral blood lymphocyte subpopulations","volume":"260","author":"Kawai","year":"2002","journal-title":"J Immunol Methods"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0135","doi-asserted-by":"crossref","first-page":"17321","DOI":"10.1074\/jbc.270.29.17321","article-title":"Integrin \u03b1IIb\u03b23\u2010mediated translocation of CDC42Hs to cytoskeleton in stimulated human platelets","volume":"270","author":"Dash","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0140","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1242\/jcs.00233","article-title":"Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone","volume":"116","author":"Nozumi","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0145","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1093\/emboj\/19.17.4589","article-title":"Scar\/WAVE\u20101, a Wiskott\u2013Aldrich syndrome protein, assembles an actin\u2010associated multi\u2010kinase scaffold","volume":"19","author":"Westphal","year":"2000","journal-title":"EMBO J"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0150","series-title":"Platelets in Thrombotic and Non\u2010Thrombotic Disorders.","first-page":"41","article-title":"Morphology and ultrastructure of platelets","author":"White","year":"2002"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0155","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1083\/jcb.119.5.1219","article-title":"Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity","volume":"119","author":"Lewis","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0160","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1182\/blood.V99.12.4466","article-title":"Arp2\/3 complex is required for actin polymerization during platelet shape change","volume":"99","author":"Li","year":"2002","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0165","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/cm.10101","article-title":"Expression of WASP and Scar1\/WAVE1 actin\u2010associated proteins is differentially modulated during differentiation of HL\u201060 cells","volume":"54","author":"Launay","year":"2003","journal-title":"Cell Motil Cytoskel"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0170","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1073\/pnas.0438033100","article-title":"Loss of WAVE\u20101 causes sensorimotor retardation and reduced learning and memory in mice","volume":"100","author":"Soderling","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0175","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1523\/JNEUROSCI.23-08-03343.2003","article-title":"Characterization of the WAVE1 knock\u2010out mouse: implications for CNS development","volume":"23","author":"Dahl","year":"2003","journal-title":"J Neurosci"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0180","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature01770","article-title":"WAVE2 is required for directed cell migration and cardiovascular development","volume":"424","author":"Yamazaki","year":"2003","journal-title":"Nature"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0185","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1093\/emboj\/cdg350","article-title":"WAVE2 deficiency reveals distinct roles in embryogenesis and Rac\u2010mediated actin\u2010based motility","volume":"22","author":"Yan","year":"2003","journal-title":"EMBO J"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0190","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1534-5807(03)00297-1","article-title":"Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration","volume":"5","author":"Suetsugu","year":"2003","journal-title":"Dev Cell"},{"key":"10.1111\/j.1538-7836.2004.01082.x_bb0195","doi-asserted-by":"crossref","first-page":"29321","DOI":"10.1074\/jbc.M111390200","article-title":"Development of platelet inhibition by cAMP during megakaryocytopoiesis","volume":"277","author":"Den Dekker","year":"2002","journal-title":"J Biol Chem"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1538-7836.2004.01082.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362213031X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153878362213031X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1538-7836.2004.01082.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:32:59Z","timestamp":1761532379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153878362213031X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S153878362213031X"],"URL":"https:\/\/doi.org\/10.1111\/j.1538-7836.2004.01082.x","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression and subcellular localization of WAVE isoforms in the megakaryocyte\/platelet lineage","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1538-7836.2004.01082.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}