{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:54:48Z","timestamp":1790142888528,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":6065,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1111\/j.1538-7836.2006.01893.x","type":"journal-article","created":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T06:19:40Z","timestamp":1144390780000},"page":"1063-1070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Increased ADAMTS\u201013 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo"],"prefix":"10.1016","volume":"4","author":[{"given":"M.","family":"NIIYA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"UEMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.W.","family":"ZHENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S.","family":"POLLAK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"DOCKAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"SCHEIFLINGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.G.","family":"WELLS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.L.","family":"ZHENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0010","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1182\/blood.V98.6.1654","article-title":"Partial amino acid sequence of purified von Willebrand factor\u2010cleaving protease","volume":"98","author":"Gerritsen","year":"2001","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0015","doi-asserted-by":"crossref","first-page":"30136","DOI":"10.1074\/jbc.M305331200","article-title":"Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13","volume":"278","author":"Zheng","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0020","doi-asserted-by":"crossref","first-page":"46643","DOI":"10.1074\/jbc.M309872200","article-title":"Cleavage of the ADAMTS13 propeptide is not required for protease activity","volume":"278","author":"Majerus","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0025","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1182\/blood-2005-03-1087","article-title":"Severe secondary deficiency of von Willebrand factor\u2010cleaving protease (ADAMTS13) in patients with sepsis\u2010induced disseminated intravascular coagulation: its correlation with development of renal failure","volume":"107","author":"Ono","year":"2006","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0030","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1182\/blood.V87.10.4223.bloodjournal87104223","article-title":"Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis","volume":"87","author":"Furlan","year":"1996","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0035","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1182\/blood-2005-03-1153","article-title":"A novel nanobody that detects the gain\u2010of\u2010function phenotype of Von Willebrand factor in adamts13 deficiency and Von Willebrand disease type 2B","volume":"106","author":"Hulstein","year":"2005","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0040","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1056\/NEJM198212023072306","article-title":"Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura","volume":"307","author":"Moake","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0045","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1098-1101(1998)13:3<126::AID-JCA6>3.0.CO;2-U","article-title":"Willebrand factor (vWf) binding to platelets associated with impaired vWf breakdown in thrombotic thrombocytopenic purpura","volume":"13","author":"Moake","year":"1998","journal-title":"J Clin Apheresis"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0050","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1056\/NEJMra020528","article-title":"Thrombotic microangiopathies","volume":"347","author":"Moake","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0055","doi-asserted-by":"crossref","first-page":"41059","DOI":"10.1074\/jbc.C100515200","article-title":"Structure of von Willebrand factor\u2010cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura","volume":"276","author":"Zheng","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0060","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/35097008","article-title":"Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura","volume":"413","author":"Levy","year":"2001","journal-title":"Nature"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0065","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/oxfordjournals.jbchem.a003009","article-title":"A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor\u2010cleaving protease","volume":"130","author":"Soejima","year":"2001","journal-title":"J Biochem (Tokyo)"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0070","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/bmj.327.7407.143","article-title":"Cirrhosis: new research provides a basis for rational and targeted treatments","volume":"327","author":"Iredale","year":"2003","journal-title":"BMJ"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0075","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1182\/blood-2005-01-0152","article-title":"Localization of ADAMTS13 to the stellate cells of human liver","volume":"106","author":"Uemura","year":"2005","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0080","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/labinvest.3700275","article-title":"ADAMTS13 is expressed in hepatic stellate cells","volume":"85","author":"Zhou","year":"2005","journal-title":"Lab Invest"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0085","doi-asserted-by":"crossref","first-page":"11721","DOI":"10.1074\/jbc.M207728200","article-title":"Smads 2 and 3 are differentially activated by transforming growth factor\u2010beta (TGF\u2010beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF\u2010beta\u2010independent","volume":"278","author":"Liu","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0090","first-page":"71","article-title":"Cellular sources of extracellular matrix proteins in normal and fibrotic liver. Studies of gene expression by in situ hybridization","volume":"22","author":"Milani","year":"1995","journal-title":"J Hepatol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0095","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/0016-5085(92)91522-6","article-title":"Meyer zum Buschenfelde KH. Synthesis of cellular fibronectin by rat liver fat\u2010storing (Ito) cells: regulation by cytokines","volume":"103","author":"Ramadori","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0100","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1016\/S0021-9258(17)34095-4","article-title":"Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo","volume":"269","author":"Friedman","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0105","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0110","doi-asserted-by":"crossref","first-page":"G245","DOI":"10.1152\/ajpgi.2000.279.2.G245","article-title":"Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis","volume":"279","author":"Arthur","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0115","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/hep.1840210328","article-title":"Increased expression of matrix metalloproteinase\u2010II in experimental liver fibrosis in rats","volume":"21","author":"Takahara","year":"1995","journal-title":"Hepatology"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0120","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1111\/jgh.1998.13.s1.33","article-title":"Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis","volume":"13","author":"Arthur","year":"1998","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0125","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s004180000150","article-title":"Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat","volume":"113","author":"Knittel","year":"2000","journal-title":"Histochem Cell Biol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0130","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1053\/jhep.2002.35625","article-title":"Tissue inhibitor of metalloproteinases\u20101 attenuates spontaneous liver fibrosis resolution in the transgenic mouse","volume":"36","author":"Yoshiji","year":"2002","journal-title":"Hepatology"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0135","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0168-8278(99)80195-0","article-title":"Myofibroblasts in the cirrhotic rat liver reflect hepatic remodeling and correlate with fibrosis and sinusoidal capillarization","volume":"30","author":"Zimmermann","year":"1999","journal-title":"J Hepatol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0140","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1478-3231.2003.00872.x","article-title":"Hepatic clearance of tissue\u2010type plasminogen activator and plasma kallikrein in experimental liver fibrosis","volume":"23","author":"Nagaoka","year":"2003","journal-title":"Liver Int"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0145","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/hep.20425","article-title":"Antifibrotic effects of a tissue inhibitor of metalloproteinase\u20101 antibody on established liver fibrosis in rats","volume":"40","author":"Parsons","year":"2004","journal-title":"Hepatology"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0150","doi-asserted-by":"crossref","first-page":"G417","DOI":"10.1152\/ajpgi.00294.2003","article-title":"Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells","volume":"287","author":"Dranoff","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.2005.05420.x","article-title":"FRETS\u2010VWF73, a first fluorogenic substrate for ADAMTS13 assay","volume":"129","author":"Kokame","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0160","doi-asserted-by":"crossref","first-page":"29428","DOI":"10.1074\/jbc.M505513200","article-title":"The proximal carboxyl\u2010terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor","volume":"280","author":"Ai","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0165","doi-asserted-by":"crossref","first-page":"D26","DOI":"10.1046\/j.1440-1746.2000.02185.x","article-title":"Molecular mechanism of the reversibility of hepatic fibrosis: with special reference to the role of matrix metalloproteinases","volume":"15","author":"Okazaki","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0170","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0002-9440(10)65703-3","article-title":"Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis","volume":"153","author":"Kossakowska","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0175","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1160\/TH04-08-0498","article-title":"Transcriptional regulation of ADAMTS13","volume":"94","author":"Claus","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0180","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1182\/blood.V98.9.2730","article-title":"Changes in health and disease of the metalloprotease that cleaves von Willebrand factor","volume":"98","author":"Mannucci","year":"2001","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0185","doi-asserted-by":"crossref","first-page":"744a","DOI":"10.1182\/blood.V106.11.2652.2652","article-title":"Biosynthesis and apical secretion of ADAMTS13 metalloprotease in vascular endothelial cells and Madin\u2010Darby canine kidney cells","volume":"106","author":"Shang","year":"2005","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0190","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1111\/j.1538-7836.2005.01561.x","article-title":"Platelet\u2010derived VWF\u2010cleaving metalloprotease ADAMTS\u201013","volume":"3","author":"Liu","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0195","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbrc.2003.11.111","article-title":"Detection of von Willebrand factor\u2010cleaving protease (ADAMTS\u201013) in human platelets","volume":"313","author":"Suzuki","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0200","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1182\/blood-2002-05-1397","article-title":"Cloning, expression, and functional characterization of the von Willebrand factor\u2010cleaving protease (ADAMTS13)","volume":"100","author":"Plaimauer","year":"2002","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0205","doi-asserted-by":"crossref","first-page":"10578","DOI":"10.1073\/pnas.0402041101","article-title":"Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13","volume":"101","author":"Nishio","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1182\/blood-2004-11-4188","article-title":"Cleavage of ultralarge multimers of von Willebrand factor by C\u2010terminal\u2010truncated mutants of ADAMTS\u201013 under flow","volume":"106","author":"Tao","year":"2005","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0215","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-2001-17552","article-title":"Extracellular matrix degradation and the role of hepatic stellate cells","volume":"21","author":"Benyon","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0220","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/bj2580463","article-title":"Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase","volume":"258","author":"Murphy","year":"1989","journal-title":"Biochem J"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0225","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1182\/blood.V87.10.4235.bloodjournal87104235","article-title":"Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion","volume":"87","author":"Tsai","year":"1996","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0230","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00062752-200209000-00001","article-title":"ADAMTS13 and TTP","volume":"9","author":"Zheng","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0235","first-page":"470","article-title":"Expression of von Willebrand factor in normal and diseased rat livers and in cultivated liver cells","volume":"21","author":"Knittel","year":"1995","journal-title":"Hepatology"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0240","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/hep.510260415","article-title":"Extracellular matrix remodeling at the early stages of liver regeneration in the rat","volume":"26","author":"Kim","year":"1997","journal-title":"Hepatology"},{"key":"10.1111\/j.1538-7836.2006.01893.x_bb0245","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/hep.510310114","article-title":"Expression and activation of pro\u2010MMP\u20102 and pro\u2010MMP\u20109 during rat liver regeneration","volume":"31","author":"Kim","year":"2000","journal-title":"Hepatology"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1538-7836.2006.01893.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622122348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622122348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1538-7836.2006.01893.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:36:41Z","timestamp":1761532601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622122348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S1538783622122348"],"URL":"https:\/\/doi.org\/10.1111\/j.1538-7836.2006.01893.x","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased ADAMTS\u201013 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1538-7836.2006.01893.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}