{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:50:58Z","timestamp":1793886658436,"version":"4.8.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":4175,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1111\/j.1538-7836.2011.04335.x","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T06:12:25Z","timestamp":1311919945000},"page":"44-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"special_numbering":"S1","title":["Novel platelet activation receptor CLEC\u20102: from discovery to prospects"],"prefix":"10.1016","volume":"9","author":[{"given":"K.","family":"SUZUKI\u2010INOUE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"INOUE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"OZAKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0010","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1042\/bj3091021","article-title":"Aggretin, a novel platelet\u2010aggregation inducer from snake (Calloselasma rhodostoma) venom, activates phospholipase C by acting as a glycoprotein Ia\/IIa agonist","volume":"309","author":"Huang","year":"1995","journal-title":"Biochem J"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0015","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1006\/bbrc.1998.8516","article-title":"Rhodocytin, a functional novel platelet agonist belonging to the heterodimeric C\u2010type lectin family, induces platelet aggregation independently of glycoprotein Ib","volume":"245","author":"Shin","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0020","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/bbrc.1999.0295","article-title":"Signal transduction pathways mediated by glycoprotein Ia\/IIa in human platelets: comparison with those of glycoprotein VI","volume":"256","author":"Inoue","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0025","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1074\/jbc.M006191200","article-title":"Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia\/IIa (GPIa\/IIa, Integrin alpha 2beta 1). Involvement of GPIa\/IIa\u2010associated src and protein tyrosine phosphorylation","volume":"276","author":"Suzuki\u2010Inoue","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0030","doi-asserted-by":"crossref","first-page":"20882","DOI":"10.1074\/jbc.M101585200","volume":"276","author":"Navdaev","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0035","doi-asserted-by":"crossref","first-page":"12274","DOI":"10.1074\/jbc.M009338200","article-title":"alpha 2beta 1 integrin is not recognized by rhodocytin but is the specific, high affinity target of rhodocetin, an RGD\u2010independent disintegrin and potent inhibitor of cell adhesion to collagen","volume":"276","author":"Eble","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0040","doi-asserted-by":"crossref","first-page":"25121","DOI":"10.1074\/jbc.M103892200","article-title":"Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand\u2010binding domain of glycoprotein Ibalpha","volume":"276","author":"Bergmeier","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0045","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood-2005-05-1994","article-title":"A novel Syk\u2010dependent mechanism of platelet activation by the C\u2010type lectin receptor CLEC\u20102","volume":"107","author":"Suzuki\u2010Inoue","year":"2006","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0050","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.coph.2008.11.001","article-title":"Thrombomodulation via CLEC\u20102 targeting","volume":"9","author":"O\u2019Callaghan","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0055","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/j.1538-7836.2010.03875.x","article-title":"GPVI and CLEC\u20102 in hemostasis and vascular integrity","volume":"8","author":"Watson","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"Suppl 1","key":"10.1111\/j.1538-7836.2011.04335.x_bb0060","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1538-7836.2009.03372.x","article-title":"Novel interactions in platelet biology: CLEC\u20102\/podoplanin and laminin\/GPVI","volume":"7","author":"Ozaki","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0065","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M","article-title":"Molecular characterization of two novel C\u2010type lectin\u2010like receptors, one of which is selectively expressed in human dendritic cells","volume":"30","author":"Colonna","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0070","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1111\/j.1538-7836.2005.01429.x","article-title":"GPVI and integrin alphaIIb beta3 signaling in platelets","volume":"3","author":"Watson","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0075","doi-asserted-by":"crossref","first-page":"12397","DOI":"10.1074\/jbc.M609558200","article-title":"The C\u2010type lectin receptors CLEC\u20102 and Dectin\u20101, but not DC\u2010SIGN, signal via a novel YXXL\u2010dependent signaling cascade","volume":"282","author":"Fuller","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0080","doi-asserted-by":"crossref","first-page":"10988","DOI":"10.1021\/bi901427d","article-title":"The platelet receptor CLEC\u20102 is active as a dimer","volume":"48","author":"Watson","year":"2009","journal-title":"Biochemistry"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0085","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1182\/blood-2009-08-237834","article-title":"CLEC\u20102 activates Syk through dimerization","volume":"115","author":"Hughes","year":"2010","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0090","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1538-7836.2009.03451.x","article-title":"The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC\u20102 signaling in platelets","volume":"7","author":"Spalton","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0095","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1074\/jbc.M110.167502","article-title":"Syk dependent phosphorylation of CLEC\u20102: a novel mechanism of hemitam signalling","volume":"286","author":"Severin","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0100","doi-asserted-by":"crossref","first-page":"39474","DOI":"10.1074\/jbc.M504672200","article-title":"Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow","volume":"280","author":"McCarty","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0105","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00424-008-0573-7","article-title":"Rac1 is essential for phospholipase C\u2010gamma2 activation in platelets","volume":"457","author":"Pleines","year":"2009","journal-title":"Pflugers Arch"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0110","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1182\/blood-2009-12-257212","article-title":"Phosphorylation of CLEC\u20102 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac","volume":"115","author":"Pollitt","year":"2010","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0115","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1182\/blood-2006-09-047449","article-title":"The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro","volume":"109","author":"Newland","year":"2007","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0120","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.4049\/jimmunol.172.10.5838","article-title":"Cutting edge: TREM\u2010like transcript\u20101, a platelet immunoreceptor tyrosine\u2010based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP\u20102","volume":"172","author":"Barrow","year":"2004","journal-title":"J Immunol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0125","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1182\/blood-2008-06-165043","article-title":"CEACAM1 negatively regulates platelet\u2010collagen interactions and thrombus growth in vitro and in vivo","volume":"113","author":"Wong","year":"2009","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0130","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/09537100600881396","article-title":"Minimal regulation of platelet activity by PECAM\u20101","volume":"18","author":"Dhanjal","year":"2007","journal-title":"Platelets"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0135","doi-asserted-by":"crossref","first-page":"35419","DOI":"10.1074\/jbc.M806895200","article-title":"G6b\u2010B inhibits constitutive and agonist\u2010induced signaling by glycoprotein VI and CLEC\u20102","volume":"283","author":"Mori","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0140","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bbrc.2009.09.087","article-title":"RACK1 associates with CLEC\u20102 and promotes its ubiquitin\u2010proteasome degradation","volume":"390","author":"Ruan","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0145","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1182\/blood-2009-12-257212","article-title":"Phosphorylation of CLEC\u20102 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac","volume":"115","author":"Pollitt","year":"2010","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0150","doi-asserted-by":"crossref","first-page":"18801","DOI":"10.1074\/jbc.M111520200","article-title":"Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI","volume":"277","author":"Locke","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0155","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1182\/blood.V99.9.3250","article-title":"Constitutive and functional association of the platelet collagen receptor glycoprotein VI\u2010Fc receptor gamma\u2010chain complex with membrane rafts","volume":"99","author":"Ezumi","year":"2002","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0160","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1042\/bj20020128","article-title":"Differential role of glycolipid\u2010enriched membrane domains in glycoprotein VI\u2010 and integrin\u2010mediated phospholipase Cgamma2 regulation in platelets","volume":"364","author":"Wonerow","year":"2002","journal-title":"Biochem J"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0165","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1084\/jem.20100222","article-title":"A novel interaction between FlnA and Syk regulates platelet ITAM\u2010mediated receptor signaling and function","volume":"207","author":"Falet","year":"2010","journal-title":"J Exp Med"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1574-6968.2008.01418.x","article-title":"The fungal pattern recognition receptor, Dectin\u20101, and the associated cluster of C\u2010type lectin\u2010like receptors","volume":"290","author":"Huysamen","year":"2009","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0175","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.immuni.2005.03.004","article-title":"Syk\u2010dependent cytokine induction by Dectin\u20101 reveals a novel pattern recognition pathway for C type lectins","volume":"22","author":"Rogers","year":"2005","journal-title":"Immunity"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0180","doi-asserted-by":"crossref","first-page":"16693","DOI":"10.1074\/jbc.M709923200","article-title":"CLEC9A is a novel activation C\u2010type lectin\u2010like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes","volume":"283","author":"Huysamen","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0185","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/ni1402","article-title":"Mutual activation of natural killer cells and monocytes mediated by NKp80\u2010AICL interaction","volume":"7","author":"Welte","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0190","doi-asserted-by":"crossref","first-page":"657","DOI":"10.4049\/jimmunol.0904117","article-title":"Cutting edge: NKp80 uses an atypical hemi\u2010ITAM to trigger NK cytotoxicity","volume":"186","author":"Dennehy","year":"2011","journal-title":"J Immunol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0195","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.4049\/jimmunol.165.6.2937","article-title":"DC\u2010SIGN; a related gene, DC\u2010SIGNR; and CD23 form a cluster on 19p13","volume":"165","author":"Soilleux","year":"2000","journal-title":"J Immunol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0200","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1182\/blood-2005-03-1252","article-title":"DC\u2010SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production","volume":"107","author":"Caparros","year":"2006","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0205","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1074\/jbc.M610383200","article-title":"The crystal structure and mutational binding analysis of the extracellular domain of the platelet\u2010activating receptor CLEC\u20102","volume":"282","author":"Watson","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0210","doi-asserted-by":"crossref","first-page":"25993","DOI":"10.1074\/jbc.M702327200","article-title":"Involvement of the snake toxin receptor CLEC\u20102, in podoplanin\u2010mediated platelet activation, by cancer cells","volume":"282","author":"Suzuki\u2010Inoue","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0215","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1349-7006.2007.00634.x","article-title":"Molecular analysis of the pathophysiological binding of the platelet aggregation\u2010inducing factor podoplanin to the C\u2010type lectin\u2010like receptor CLEC\u20102","volume":"99","author":"Kato","year":"2008","journal-title":"Cancer Sci"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0220","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1110\/ps.035568.108","article-title":"Crystal structure of rhodocytin, a ligand for the platelet\u2010activating receptor CLEC\u20102","volume":"17","author":"Watson","year":"2008","journal-title":"Protein Sci"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0225","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.1021\/bi800528t","article-title":"The crystal structure of the platelet activator aggretin reveals a novel (alphabeta)2 dimeric structure","volume":"47","author":"Hooley","year":"2008","journal-title":"Biochemistry"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0230","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1128\/JVI.00136-06","article-title":"DC\u2010SIGN and CLEC\u20102 mediate human immunodeficiency virus type 1 capture by platelets","volume":"80","author":"Chaipan","year":"2006","journal-title":"J Virol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0235","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nbt.1644","article-title":"A mouse knockout library for secreted and transmembrane proteins","volume":"28","author":"Tang","year":"2010","journal-title":"Nat Biotechnol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0240","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1074\/mcp.D600007-MCP200","article-title":"A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b\u2010B, a novel immunoreceptor tyrosine\u2010based inhibitory motif protein","volume":"6","author":"Senis","year":"2007","journal-title":"Mol Cell Proteomics"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0245","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.4049\/jimmunol.0802808","article-title":"CLEC\u20102 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils","volume":"182","author":"Kerrigan","year":"2009","journal-title":"J Immunol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0250","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1111\/j.1538-7836.2010.04045.x","article-title":"A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C\u2010type lectin protein, through CLEC\u20102 ligation","volume":"8","author":"Chang","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0255","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(02)00789-1","article-title":"Platelets and cancer","volume":"3","author":"Nash","year":"2002","journal-title":"Lancet Oncol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0260","first-page":"1286","article-title":"Characterization of platelet aggregation induced by the human melanoma cell line HMV\u2010I: roles of heparin, plasma adhesive proteins, and tumor cell membrane proteins","volume":"51","author":"Katagiri","year":"1991","journal-title":"Cancer Res"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0265","first-page":"537","article-title":"Involvement of platelet membrane glycoprotein Ib and glycoprotein IIb\/IIIa complex in thrombin\u2010dependent and \u2010independent platelet aggregations induced by tumor cells","volume":"49","author":"Kitagawa","year":"1989","journal-title":"Cancer Res"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0270","doi-asserted-by":"crossref","first-page":"51599","DOI":"10.1074\/jbc.M309935200","article-title":"Molecular identification of Aggrus\/T1alpha as a platelet aggregation\u2010inducing factor expressed in colorectal tumors","volume":"278","author":"Kato","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0275","first-page":"1295","article-title":"Lysis of tumor cells by natural killer cells in mice is impeded by platelets","volume":"59","author":"Nieswandt","year":"1999","journal-title":"Cancer Res"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0280","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0002-9440(10)62311-5","article-title":"Up\u2010regulation of the lymphatic marker podoplanin, a mucin\u2010type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors","volume":"166","author":"Schacht","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0285","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000086952","article-title":"Enhanced expression of Aggrus (T1alpha\/podoplanin), a platelet\u2010aggregation\u2010inducing factor in lung squamous cell carcinoma","volume":"26","author":"Kato","year":"2005","journal-title":"Tumour Biol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0290","doi-asserted-by":"crossref","first-page":"8552","DOI":"10.1038\/sj.onc.1207869","article-title":"Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors","volume":"23","author":"Kato","year":"2004","journal-title":"Oncogene"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0295","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00401-006-0063-y","article-title":"Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression","volume":"111","author":"Mishima","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0300","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00401-006-0033-4","article-title":"Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma","volume":"111","author":"Mishima","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0305","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.bbrc.2006.08.171","article-title":"Inhibition of tumor cell\u2010induced platelet aggregation using a novel anti\u2010podoplanin antibody reacting with its platelet\u2010aggregation\u2010stimulating domain","volume":"349","author":"Kato","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0310","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2183\/pjab.84.189","article-title":"Platelet aggregation in the formation of tumor metastasis","volume":"84","author":"Tsuruo","year":"2008","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0315","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/cncr.22061","article-title":"Overexpression of podoplanin in oral cancer and its association with poor clinical outcome","volume":"107","author":"Yuan","year":"2006","journal-title":"Cancer"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0320","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/BJ20071216","article-title":"Renal cells activate the platelet receptor CLEC\u20102 through podoplanin","volume":"411","author":"Christou","year":"2008","journal-title":"Biochem J"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0325","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ccr.2006.03.010","article-title":"Tumor invasion in the absence of epithelial\u2010mesenchymal transition: podoplanin\u2010mediated remodeling of the actin cytoskeleton","volume":"9","author":"Wicki","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0330","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/ijc.20656","article-title":"Characterization of human PA2.26 antigen (T1alpha\u20102, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas","volume":"113","author":"Martin\u2010Villar","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0335","doi-asserted-by":"crossref","first-page":"397","DOI":"10.5858\/2008-132-397-AOITTD","article-title":"Application of immunohistochemistry to the diagnosis of malignant mesothelioma","volume":"132","author":"Marchevsky","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0340","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: molecular mechanisms and future promise","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0345","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1126\/science.1079477","article-title":"Regulation of blood and lymphatic vascular separation by signaling proteins SLP\u201076 and Syk","volume":"299","author":"Abtahian","year":"2003","journal-title":"Science"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0350","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1093\/emboj\/cdg342","article-title":"T1alpha\/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema","volume":"22","author":"Schacht","year":"2003","journal-title":"EMBO J"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0355","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2009-04-216069","article-title":"Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation","volume":"115","author":"Uhrin","year":"2010","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0360","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1172\/JCI36077","article-title":"Endothelial cell O\u2010glycan deficiency causes blood\/lymphatic misconnections and consequent fatty liver disease in mice","volume":"118","author":"Fu","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0365","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1161\/CIRCRESAHA.110.218073","article-title":"Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis","volume":"106","author":"Carramolino","year":"2010","journal-title":"Circ Res"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0370","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.yexcr.2009.02.021","article-title":"Galectin\u20108 interacts with podoplanin and modulates lymphatic endothelial cell functions","volume":"315","author":"Cueni","year":"2009","journal-title":"Exp Cell Res"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0375","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCULATIONAHA.109.910703","article-title":"Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor\u20103 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts","volume":"121","author":"Nykanen","year":"2010","journal-title":"Circulation"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0380","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1182\/blood-2010-02-270876","article-title":"Platelets regulate lymphatic vascular development through CLEC\u20102\u2010SLP\u201076 signaling","volume":"116","author":"Bertozzi","year":"2010","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0385","first-page":"24494","article-title":"Essential in vivo roles of the C\u2010type lectin receptor CLEC\u20102: embryonic\/neonatal lethality of CLEC\u20102\u2010deficient mice by blood\/lymphatic misconnections and impaired thrombus formation of CLEC\u20102\u2010deficient platelets","volume":"285","author":"Suzuki\u2010Inoue","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0390","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nm1722","article-title":"Kindlin\u20103 is essential for integrin activation and platelet aggregation","volume":"14","author":"Moser","year":"2008","journal-title":"Nat Med"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0395","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1182\/blood-2009-05-222273","article-title":"CLEC\u20102 is an essential platelet\u2010activating receptor in hemostasis and thrombosis","volume":"114","author":"May","year":"2009","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0400","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1172\/JCI19284","article-title":"Antithrombotic activity of TNF\u2010alpha","volume":"112","author":"Cambien","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0405","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1182\/blood-2005-10-4244","article-title":"Thrombin overcomes the thrombosis defect associated with platelet GPVI\/FcRgamma deficiency","volume":"107","author":"Mangin","year":"2006","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0410","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.193.4.459","article-title":"Long\u2010term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice","volume":"193","author":"Nieswandt","year":"2001","journal-title":"J Exp Med"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0415","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1182\/blood.V69.6.1712.1712","article-title":"A novel platelet aggregating factor found in a patient with defective collagen\u2010induced platelet aggregation and autoimmune thrombocytopenia","volume":"69","author":"Sugiyama","year":"1987","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0420","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1172\/JCI114318","article-title":"A patient with platelets deficient in glycoprotein VI that lack both collagen\u2010induced aggregation and adhesion","volume":"84","author":"Moroi","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0425","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1111\/j.1538-7836.2010.04006.x","article-title":"CLEC\u20102 is not required for platelet aggregation at arteriolar shear","volume":"8","author":"Hughes","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0430","doi-asserted-by":"crossref","DOI":"10.1186\/1742-4690-7-47","article-title":"Incorporation of podoplanin into HIV released from HEK\u2010293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC\u20102","volume":"7","author":"Chaipan","year":"2010","journal-title":"Retrovirology"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0435","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1054\/blre.2001.0188","article-title":"HIV\u2010related thrombocytopenia","volume":"16","author":"Scaradavou","year":"2002","journal-title":"Blood Rev"},{"key":"10.1111\/j.1538-7836.2011.04335.x_bb0440","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/107602960401000311","article-title":"Thrombosis and a hypercoagulable state in HIV\u2010infected patients","volume":"10","author":"Shen","year":"2004","journal-title":"Clin Appl Thromb Hemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1538-7836.2011.04335.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622055295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622055295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1538-7836.2011.04335.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:54:01Z","timestamp":1761533641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622055295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":87,"alternative-id":["S1538783622055295"],"URL":"https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04335.x","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel platelet activation receptor CLEC\u20102: from discovery to prospects","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04335.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}