{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:05:58Z","timestamp":1792757158470,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":4113,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1111\/j.1538-7836.2011.04430.x","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T17:22:32Z","timestamp":1309886552000},"page":"1816-1824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Alterations in coagulation and fibrinolysis after levothyroxine exposure in healthy volunteers: a controlled randomized crossover study"],"prefix":"10.1016","volume":"9","author":[{"given":"B.","family":"VAN ZAANE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"SQUIZZATO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"DEBEIJ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.M.","family":"DEKKERS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.M.","family":"MEIJERS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.P.","family":"VAN ZANTEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.R.","family":"B\u00dcLLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.E.A.","family":"GERDES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"CANNEGIETER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.M.","family":"BRANDJES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0010","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1001\/archneurpsyc.1927.02210030054004","article-title":"Obstruction of the longitudinal sinus","volume":"29","author":"Doyle","year":"1927","journal-title":"Arch Neurol Psychiatry"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0015","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/MAJ.0b013e3181adb4c4","article-title":"Thyrotoxicosis causing arterial and venous thrombosis","volume":"338","author":"Lodha","year":"2009","journal-title":"Am J Med Sci"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0020","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000087717","article-title":"Hyperthyroidism and cerebral venous thrombosis","volume":"54","author":"Mouton","year":"2005","journal-title":"Eur Neurol"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0025","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/01.STR.26.3.496","article-title":"Superior sagittal sinus thrombosis and thyrotoxicosis. Possible association in two cases","volume":"26","author":"Siegert","year":"1995","journal-title":"Stroke"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0030","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/MBC.0b013e3282f09de2","article-title":"Recurrent deep venous thrombosis during optimal anticoagulation and overt hyperthyroidism: a case report","volume":"18","author":"Squizzato","year":"2007","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0035","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1089\/thy.2000.10.607","article-title":"Thyrotoxicosis as a predisposing factor for cerebral venous thrombosis","volume":"10","author":"Verberne","year":"2000","journal-title":"Thyroid"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0040","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1177\/1076029609336856","article-title":"Venous thromboembolism in patients hospitalized with thyroid dysfunction","volume":"15","author":"Danescu","year":"2009","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0045","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1055\/s-0029-1222607","article-title":"Thyroid dysfunction and hemostasis: an issue still unresolved","volume":"35","author":"Franchini","year":"2009","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0050","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1160\/TH06-12-0682","article-title":"Subclinical hypothyroidism and deep venous thrombosis. A pilot cross\u2010sectional study","volume":"97","author":"Squizzato","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0055","article-title":"Increased levels of thyroxin increase the risk of venous thrombosis","volume":"7","author":"Cannegieter","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0060","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1182\/blood-2009-11-253724","article-title":"Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case\u2010control study","volume":"115","author":"van Zaane","year":"2010","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0030-1270067","article-title":"Thyroid disorders and hypercoagulability","volume":"37","author":"Erem","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0070","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1210\/jc.2007-0199","article-title":"Clinical review: thyroid dysfunction and effects on coagulation and fibrinolysis: a systematic review","volume":"92","author":"Squizzato","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0075","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1111\/j.1538-7836.2010.04054.x","article-title":"The effect of changes in thyroxine and thyroid\u2010stimulating hormone levels on the coagulation system","volume":"8","author":"Debeij","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0080","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2265.2008.03497.x","article-title":"Levothyroxine (LT4) suppression treatment for benign thyroid nodules alters coagulation","volume":"71","author":"Demir","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0085","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1210\/jc.2006-2644","article-title":"Altered platelet plug formation in hyperthyroidism and hypothyroidism","volume":"92","author":"Homoncik","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0090","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1538-7836.2010.03854.x","article-title":"The effects of an extremely high dose of levothyroxine on coagulation and fibrinolysis","volume":"8","author":"Stuijver","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0095","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1210\/jcem-63-2-407","article-title":"Effect of thyroid hormones on plasma protein concentrations in man","volume":"63","author":"Graninger","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0100","first-page":"444","article-title":"Factor VIII activity in normal volunteers receiving oral thyroid hormone","volume":"102","author":"Rogers","year":"1983","journal-title":"J Lab Clin Med"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1089\/105072501300042820","article-title":"Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol","volume":"11","author":"Burggraaf","year":"2001","journal-title":"Thyroid"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0110","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1210\/jc.2004-0536","article-title":"Is thyroid hormone suppression therapy prothrombotic?","volume":"89","author":"Horne","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1055\/s-2007-1003766","article-title":"Activation of blood coagulation and fibrinolysis in Graves\u2019 disease","volume":"23","author":"Marongiu","year":"1991","journal-title":"Horm Metab Res"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000073575","article-title":"The calibrated automated thrombogram (CAT): a universal routine test for hyper\u2010 and hypocoagulability","volume":"32","author":"Hemker","year":"2002","journal-title":"Pathophysiol Haemost Thromb"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0125","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-2516.2005.01107.x","article-title":"Thrombin generation and phenotypic correlation in haemophilia A","volume":"11","author":"Beltran\u2010Miranda","year":"2005","journal-title":"Haemophilia"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1538-7836.2007.02824.x","article-title":"Coagulation factors and the protein C system as determinants of thrombin generation in a normal population","volume":"6","author":"Dielis","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0135","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1538-7836.2010.03854.x","article-title":"The effects of an extremely high dose of levothyroxine on coagulation and fibrinolysis","volume":"8","author":"Stuyver","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0140","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1182\/blood-2004-08-3253","article-title":"Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis","volume":"105","author":"Lisman","year":"2005","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0145","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1371\/journal.pmed.0050097","article-title":"Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis","volume":"5","author":"Meltzer","year":"2008","journal-title":"PLoS Med"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0150","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0155","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11239-009-0327-1","article-title":"Thyroid\u2010associated autoimmune coagulation disorders","volume":"29","author":"Franchini","year":"2010","journal-title":"J Thromb Thrombolysis"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0160","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1182\/blood.V91.8.2810.2810_2810_2817","article-title":"Recurrent arterial thrombosis linked to autoimmune antibodies enhancing von Willebrand factor binding to platelets and inducing Fc gamma RII receptor\u2010mediated platelet activation","volume":"91","author":"Hoylaerts","year":"1998","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0165","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM200102153440707","article-title":"Thyroid hormone and the cardiovascular system","volume":"344","author":"Klein","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0170","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/07435809309033019","article-title":"Elevated plasma levels of VWF:Ag in hyperthyroidism are mediated through beta\u2010adrenergic receptors","volume":"19","author":"Liu","year":"1993","journal-title":"Endocr Res"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0175","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1016\/j.atherosclerosis.2008.09.022","article-title":"Thyroid function is associated with carotid intima\u2010media thickness in euthyroid subjects","volume":"204","author":"Takamura","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0180","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1055\/s-0038-1656135","article-title":"Epinephrine induces von Willebrand factor release from cultured endothelial cells: involvement of cyclic AMP\u2010dependent signalling in exocytosis","volume":"77","author":"Vischer","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0185","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1677\/joe.0.1540231","article-title":"Increase by tri\u2010iodothyronine of endothelin\u20101, fibronectin and von Willebrand factor in cultured endothelial cells","volume":"154","author":"Baumgartner\u2010Parzer","year":"1997","journal-title":"J Endocrinol"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0190","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1055\/s-0038-1649798","article-title":"The influence of insulin, beta\u2010estradiol, dexamethasone and thyroid hormone on the secretion of coagulant and anticoagulant proteins by HepG2 cells","volume":"74","author":"Niessen","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0195","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1210\/en.2003-1372","article-title":"Thyroid hormone receptor\u2010dependent transcriptional regulation of fibrinogen and coagulation proteins","volume":"145","author":"Shih","year":"2004","journal-title":"Endocrinology"},{"key":"10.1111\/j.1538-7836.2011.04430.x_bb0200","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1056\/NEJMoa0905633","article-title":"Use of the thyroid hormone analogue eprotirome in statin\u2010treated dyslipidemia","volume":"362","author":"Ladenson","year":"2010","journal-title":"N Engl J Med"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1538-7836.2011.04430.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622071264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622071264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1538-7836.2011.04430.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:56:21Z","timestamp":1761533781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622071264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S1538783622071264"],"URL":"https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04430.x","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations in coagulation and fibrinolysis after levothyroxine exposure in healthy volunteers: a controlled randomized crossover study","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04430.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}