{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:05:50Z","timestamp":1790694350146,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":4022,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1111\/j.1538-7836.2011.04517.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T17:27:01Z","timestamp":1317144421000},"page":"2337-2344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Sex differences in the relationship between inflammatory and hemostatic biomarkers and metabolic syndrome: British 1958 Birth Cohort"],"prefix":"10.1016","volume":"9","author":[{"given":"A.R.","family":"RUDNICKA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"RUMLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.H.","family":"WHINCUP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.D.","family":"LOWE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.","family":"STRACHAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0010","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa032804","article-title":"C\u2010reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease","volume":"350","author":"Danesh","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0015","first-page":"1799","article-title":"Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta\u2010analysis","volume":"294","year":"2005","journal-title":"JAMA"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0020","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1161\/01.CIR.103.19.2323","article-title":"Fibrin D\u2010dimer and coronary heart disease: prospective study and meta\u2010analysis","volume":"103","author":"Danesh","year":"2001","journal-title":"Circulation"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0025","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1053\/euhj.2001.3237","article-title":"von Willebrand factor and coronary heart disease: prospective study and meta\u2010analysis","volume":"23","author":"Whincup","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0030","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ehj.2003.11.004","article-title":"Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta\u2010analysis","volume":"25","author":"Lowe","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0035","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","article-title":"Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association","volume":"107","author":"Pearson","year":"2003","journal-title":"Circulation"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0040","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.04.006","article-title":"Inflammation and hemostasis biomarkers for predicting stroke in postmenopausal women: the Women\u2019s Health Initiative Observational Study","volume":"17","author":"Kaplan","year":"2008","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0045","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1093\/eurheartj\/ehp115","article-title":"Do inflammatory biomarkers add to the discrimination of cardiovascular disease after allowing for social deprivation? Results from a 10\u2003year cohort study in Glasgow, Scotland","volume":"31","author":"Woodward","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0050","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/ije\/dyn217","article-title":"Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts","volume":"38","author":"Shah","year":"2009","journal-title":"Int J Epidemiol"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0055","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.CIR.0000055014.62083.05","article-title":"C\u2010reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8\u2010year follow\u2010up of 14 719 initially healthy American women","volume":"107","author":"Ridker","year":"2003","journal-title":"Circulation"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0060","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0065","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.metabol.2010.05.015","article-title":"Systemic inflammation and the metabolic syndrome among middle\u2010aged community volunteers","volume":"59","author":"Marsland","year":"2010","journal-title":"Metabolism"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0070","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/diacare.25.11.2016","article-title":"Prospective study of C\u2010reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study","volume":"25","author":"Han","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/01.CIR.0000136581.59584.0E","article-title":"C\u2010reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study","volume":"110","author":"Rutter","year":"2004","journal-title":"Circulation"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0080","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5551\/jat.1529","article-title":"Associations of fibrinogen with metabolic syndrome in rural Chinese population","volume":"17","author":"Ma","year":"2010","journal-title":"J Atheroscler Thromb"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0085","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s00125-009-1338-3","article-title":"Association of C\u2010reactive protein with type 2 diabetes: prospective analysis and meta\u2010analysis","volume":"52","author":"Lee","year":"2009","journal-title":"Diabetologia"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0090","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/CIRCULATIONAHA.106.635169","article-title":"Diurnal, seasonal, and blood\u2010processing patterns in levels of circulating fibrinogen, fibrin D\u2010dimer, C\u2010reactive protein, tissue plasminogen activator, and von Willebrand factor in a 45\u2010year\u2010old population","volume":"115","author":"Rudnicka","year":"2007","journal-title":"Circulation"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0095","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/aje\/kwn055","article-title":"Effects of socioeconomic position on inflammatory and hemostatic markers: a life\u2010course analysis in the 1958 British birth cohort","volume":"167","author":"Tabassum","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0100","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/ije\/dyl309","article-title":"Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood","volume":"36","author":"Strachan","year":"2007","journal-title":"Int J Epidemiol"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0105","first-page":"237","article-title":"Rapid physiological coagulation method in determination of fibrinogen","volume":"17","author":"von Clauss","year":"1957","journal-title":"Acta Haematol"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0110","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0140-6736(05)67402-8","article-title":"The metabolic syndrome\u2010\u2010a new worldwide definition","volume":"366","author":"Alberti","year":"2005","journal-title":"Lancet"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0115","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1136\/jech.2006.058966","article-title":"Loss and representativeness in a biomedical survey at age 45\u2003years: 1958 British birth cohort","volume":"62","author":"Atherton","year":"2008","journal-title":"J Epidemiol Community Health"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0120","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1001\/archinte.165.18.2063","article-title":"High attributable risk of elevated C\u2010reactive protein level to conventional coronary heart disease risk factors: the Third National Health and Nutrition Examination Survey","volume":"165","author":"Miller","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0125","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/aje\/kwm191","volume":"166","author":"Kaptoge","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0130","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.amjcard.2007.07.061","article-title":"Prevalence and risk factor correlates of elevated C\u2010reactive protein in an adult Australian population","volume":"101","author":"Hung","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2004.12.031","article-title":"The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non\u2010diabetic men","volume":"181","author":"Wannamethee","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0140","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ahj.2006.02.015","article-title":"Gender and C\u2010reactive protein: data from the Multiethnic Study of Atherosclerosis (MESA) cohort","volume":"152","author":"Lakoski","year":"2006","journal-title":"Am Heart J"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0145","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.atherosclerosis.2005.04.011","article-title":"Sex differences in the relation of body composition to markers of inflammation","volume":"184","author":"Thorand","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0150","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/dmrr.561","article-title":"The metabolic syndrome and high C\u2010reactive protein: prevalence and differences by sex in a southern\u2010European population\u2010based cohort","volume":"21","author":"Bo","year":"2005","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0155","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00001721-200309000-00009","article-title":"Associations of haemostatic variables with body mass index: a community\u2010based study","volume":"14","author":"Bowles","year":"2003","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0160","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.metabol.2008.04.015","article-title":"Exploring the usefulness of inflammation\u2010sensitive biomarkers to reveal potential sex differences in relation to low\u2010grade inflammation in individuals with the metabolic syndrome","volume":"57","author":"Rogowski","year":"2008","journal-title":"Metabolism"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0165","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1464-5491.2008.02440.x","article-title":"Gender differences in C\u2010reactive protein, interleukin\u20101 receptor antagonist and adiponectin levels in the metabolic syndrome: a population\u2010based study","volume":"25","author":"Saltevo","year":"2008","journal-title":"Diabet Med"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0170","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1210\/jcem.86.9.7873","article-title":"Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study","volume":"86","author":"Hak","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0175","doi-asserted-by":"crossref","first-page":"854","DOI":"10.2337\/dc06-1693","article-title":"Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA\/KORA Augsburg case\u2010cohort study, 1984\u20132002","volume":"30","author":"Thorand","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0180","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.2337\/diacare.26.5.1657","article-title":"Prospective relation of C\u2010reactive protein with type 2 diabetes: response to Snijder et\u00a0al.","volume":"26","author":"Sattar","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0185","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/jama.286.3.327","article-title":"C\u2010reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus","volume":"286","author":"Pradhan","year":"2001","journal-title":"JAMA"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0190","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.2337\/diacare.26.5.1656","article-title":"Prospective relation of C\u2010reactive protein with type 2 diabetes: response to Han et\u00a0al.","volume":"26","author":"Snijder","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0195","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/eurheartj\/ehi052","article-title":"Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study","volume":"26","author":"Yarnell","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0200","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1111\/j.1538-7836.2007.02677.x","article-title":"A comparison of the associations between seven hemostatic or inflammatory variables and coronary heart disease","volume":"5","author":"Woodward","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0205","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3945\/ajcn.2008.27030","article-title":"Sex differences in inflammatory markers: what is the contribution of visceral adiposity?","volume":"89","author":"Cartier","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0210","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/jc.2008-2406","article-title":"Sex differences in the relationship between C\u2010reactive protein and body fat","volume":"94","author":"Khera","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/j.1538-7836.2011.04517.x_bb0215","series-title":"Changes in the NCDS and BSC70 Populations and Samples Over Time","author":"Plewis","year":"2004"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1538-7836.2011.04517.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622074669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622074669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1538-7836.2011.04517.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:55:59Z","timestamp":1761533759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622074669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1538783622074669"],"URL":"https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04517.x","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in the relationship between inflammatory and hemostatic biomarkers and metabolic syndrome: British 1958 Birth Cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04517.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}