{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:17:13Z","timestamp":1791753433783,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":3992,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1111\/j.1538-7836.2011.04553.x","type":"journal-article","created":{"date-parts":[[2011,11,25]],"date-time":"2011-11-25T11:43:32Z","timestamp":1322221412000},"page":"64-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":176,"title":["Low\u2010molecular\u2010weight heparin added to aspirin in the prevention of recurrent early\u2010onset pre\u2010eclampsia in women with inheritable thrombophilia: the FRUIT\u2010RCT"],"prefix":"10.1016","volume":"10","author":[{"given":"J.I.P.","family":"DE VRIES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.","family":"VAN PAMPUS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.M.","family":"HAGUE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.D.","family":"BEZEMER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.","family":"JOOSTEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0010","first-page":"83","article-title":"Recurrence rate of pre\u2010eclampsia in women with thrombophilia influenced by low\u2010molecular\u2010weight heparin treatment?","volume":"62","author":"Kalk","year":"2004","journal-title":"Neth J Med"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0015","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1001\/jama.287.24.3183","article-title":"Contemporary concepts of the pathogenesis and management of preeclampsia","volume":"287","author":"Lain","year":"2002","journal-title":"JAMA"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1160\/TH07-05-0373","article-title":"Thrombophilias and adverse pregnancy outcome \u2013 A confounded problem!","volume":"99","author":"Kist","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0025","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre\u2010eclampsia: a meta\u2010analysis of individual patient data","volume":"369","author":"Askie","year":"2007","journal-title":"Lancet"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0030","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta\u2010analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0035","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(10)60709-X","article-title":"Antiphospholipid syndrome","volume":"376","author":"Ruiz\u2010Irastorza","year":"2010","journal-title":"Lancet"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3899\/jrheum.080763","article-title":"Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial","volume":"36","author":"Laskin","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0301-2115(98)00083-9","article-title":"Low\u2010molecular\u2010weight heparin combined with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study","volume":"80","author":"Riyazi","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0050","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3109\/14767058.2010.545911","article-title":"Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications","volume":"24","author":"Kupferminc","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0055","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S1701-2163(16)32641-X","article-title":"Dalteparin and low\u2010dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia","volume":"29","author":"Leduc","year":"2007","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0060","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1034\/j.1600-0412.2000.079006440.x","article-title":"Birthweight by gestational age in Norway","volume":"79","author":"Skjaerven","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0049-3848(87)90201-5","article-title":"Protein C: comparison of different assays in normal and abnormal plasma samples","volume":"46","author":"Vinazzer","year":"1987","journal-title":"Thromb Res"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0049-3848(88)90189-2","article-title":"The simultaneous measurement of total and free protein S by ELISA","volume":"50","author":"Woodhams","year":"1988","journal-title":"Thromb Res"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0075","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0140-6736(05)80081-9","article-title":"Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study","volume":"342","author":"Koster","year":"1993","journal-title":"Lancet"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0080","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/0002-9378(93)90378-V","article-title":"Osteoporotic fractures and the recurrence of thromboembolism during pregnancy and the puerperium in 184 women undergoing thromboprophylaxis with heparin","volume":"168","author":"Dahlman","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0085","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1055\/s-0037-1614550","article-title":"Safety of low\u2010molecular\u2010weight heparin in pregnancy: a systematic review","volume":"81","author":"Sanson","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0090","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/10641950701521601","article-title":"Relationship between thrombophilic disorders and type of severe early\u2010onset hypertensive disorder of pregnancy","volume":"26","author":"Ganzevoort","year":"2007","journal-title":"Hypertens Pregnancy"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0095","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/j.1538-7836.2007.02634.x","article-title":"Long\u2010term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial","volume":"5","author":"Rodger","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0100","doi-asserted-by":"crossref","first-page":"b2255","DOI":"10.1136\/bmj.b2255","article-title":"Risk of pre\u2010eclampsia in first and subsequent pregnancies: prospective cohort study","volume":"338","author":"Hernandez\u2010Diaz","year":"2009","journal-title":"BMJ"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0105","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/bmj.38380.674340.E0","article-title":"Risk factors for pre\u2010eclampsia at antenatal booking: systematic review of controlled studies","volume":"330","author":"Duckitt","year":"2005","journal-title":"BMJ"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1538-7836.2008.03230.x","article-title":"Dalteparin for the prevention of recurrence of placental\u2010mediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial","volume":"7","author":"Rey","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0115","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1097\/AOG.0b013e31821b5384","article-title":"Angiogenic response of placental villi to heparin","volume":"117","author":"Sobel","year":"2011","journal-title":"Obstet Gynecol"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0120","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1161\/CIRCRESAHA.110.239665","article-title":"Local retention versus systemic release of soluble VEGF receptor\u20101 are mediated by heparin\u2010binding and regulated by heparanase","volume":"108","author":"Sela","year":"2011","journal-title":"Circ Res"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1160\/TH06-10-0574","article-title":"The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia","volume":"98","author":"Abou\u2010Nassar","year":"2007","journal-title":"A randomized trial. Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/S0965539510000070","article-title":"Heparin in human placental development and the prevention of placental complications of pregnancy","volume":"21","author":"Drewlo","year":"2010","journal-title":"Fetal and Maternal Medicine Review"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0135","first-page":"90","article-title":"Evaluation of an optimal dose of low\u2010molecular\u2010weight heparin for thromboprophylaxis in pregnant women at risk of thrombosis using coagulation activation markers","volume":"31","author":"Bombeli","year":"2001","journal-title":"Haemostasis"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0140","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1182\/blood-2003-12-4250","article-title":"Low\u2010molecular\u2010weight heparin versus low\u2010dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder","volume":"103","author":"Gris","year":"2004","journal-title":"Blood"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0145","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1056\/NEJMoa1000641","article-title":"Aspirin plus heparin or aspirin alone in women with recurrent miscarriage","volume":"362","author":"Kaandorp","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1538-7836.2011.04553.x_bb0150","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jsgi.2004.02.007","article-title":"Pharmacokinetics of low molecular weight heparin and unfractionated heparin in pregnancy","volume":"11","author":"Ensom","year":"2004","journal-title":"J Soc Gynecol Investig"}],"updated-by":[{"DOI":"10.1111\/jth.12811","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000}}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1538-7836.2011.04553.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622061384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622061384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1538-7836.2011.04553.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T01:36:15Z","timestamp":1713144975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622061384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1538783622061384"],"URL":"https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04553.x","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low\u2010molecular\u2010weight heparin added to aspirin in the prevention of recurrent early\u2010onset pre\u2010eclampsia in women with inheritable thrombophilia: the FRUIT\u2010RCT","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04553.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}