{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:15:16Z","timestamp":1792516516548,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":3780,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1111\/j.1538-7836.2012.04801.x","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T11:23:46Z","timestamp":1338377026000},"page":"1547-1555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Relation of psychological distress to the international normalized ratio in patients with venous thromboembolism with and without oral anticoagulant therapy"],"prefix":"10.1016","volume":"10","author":[{"given":"R.","family":"VON K\u00c4NEL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"V\u00d6KT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. DEMARMELS","family":"BIASIUTTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"STAUBER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.A.","family":"WUILLEMIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"LUKAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0010","series-title":"Hemostasis and Thrombosis. Basic Principles & Clinical Practice","first-page":"1498","article-title":"Practical aspects of anticoagulant therapy","author":"Crowther","year":"2000"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0015","doi-asserted-by":"crossref","first-page":"w13502","DOI":"10.4414\/smw.2012.13502","article-title":"Psychosocial stress and cardiovascular disease \u2013 current opinion","volume":"142","author":"von K\u00e4nel","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12160-011-9274-0","article-title":"Hemoconcentration and hemostasis during acute stress: interacting and independent effects","volume":"42","author":"Austin","year":"2011","journal-title":"Ann Behav Med"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0025","series-title":"Stress and Cardiovascular Disease","first-page":"89","article-title":"Haemostatic effects of stress","author":"Hjemdahl","year":"2012"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0030","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1538-7836.2007.02401.x","article-title":"ISTH SSC subcommittee on women\u2019s health issues preanalytical conditions that affect coagulation testing, including hormonal status and therapy","volume":"5","author":"Blomb\u00e4ck","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0035","first-page":"160S","article-title":"American college of chest physicians. Pharmacology and management of the vitamin K antagonists: American college of chest physicians evidence\u2010based clinical practice guidelines (8th Edition)","volume":"133","author":"Ansell","year":"2008"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0040","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1469-8986.2007.00536.x","article-title":"Time course and mechanisms of mental stress\u2010induced changes and their recovery: hematocrit, colloid osmotic pressure, whole blood viscosity, coagulation times, and hemodynamic activity","volume":"44","author":"De Boer","year":"2007","journal-title":"Psychophysiology"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0045","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.thromres.2008.05.014","article-title":"Prothrombotic changes with acute psychological stress: combined effect of hemoconcentration and genuine coagulation activation","volume":"123","author":"von K\u00e4nel","year":"2009","journal-title":"Thromb Res"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0050","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/PSY.0b013e318245d950","article-title":"Stress\u2010induced alterations in coagulation: assessment of a new hemoconcentration correction technique","volume":"74","author":"Austin","year":"2012","journal-title":"Psychosom Med"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0002-9149(96)00680-7","article-title":"Changes in hemostatic function at times of cyclic variation in occupational stress","volume":"79","author":"Frimerman","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0060","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1345\/aph.1A263","article-title":"Effect of stress on international normalized ratio during warfarin therapy","volume":"36","author":"Hawk","year":"2002","journal-title":"Ann Pharmacother"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0065","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0889-1591(03)00048-5","article-title":"The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X","volume":"17","author":"Black","year":"2003","journal-title":"Brain Behav Immun"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2012.04.011","article-title":"Depressive symptoms, perceived social support, and prothrombotic measures in patients with venous thromboembolism","author":"Lukas","year":"2012","journal-title":"Thromb Res"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0075","series-title":"HADS\u2010D Hospital Anxiety and Depression Scale Deutsche Version: ein Fragebogen zur Erfassung von Angst und Depressivit\u00e4t in der somatischen Medizin","author":"Herrmann","year":"1995"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0085","first-page":"50","article-title":"Besorgnis: ein vergleich dreier inventare zur erfassung allgemeiner Sorgen","volume":"16","author":"St\u00f6ber","year":"1995","journal-title":"Zschr Diff Diagn Psychol"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0090","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0005-7967(98)00031-X","article-title":"Weekly assessment of worry: an adaptation of the Penn state worry questionnaire for monitoring changes during treatment","volume":"36","author":"St\u00f6ber","year":"1998","journal-title":"Behav Res Ther"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0095","first-page":"53","article-title":"Skalen zur erfassung des wohlbefindens psychometrische \u00fcberpr\u00fcfung des Profile of Mood States (POMS)","volume":"11","author":"Bullinger","year":"1990","journal-title":"Zschr Diff Diagn Psychol"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0100","series-title":"Profile of Mood States Instrument","author":"McNair","year":"1971"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0105","first-page":"7","article-title":"A comparison of the Cook\u2010Medley Hostility Scale (Ho scale) and the content scales \u2018cynicism\u2019, \u2018anger\u2019, and \u2018type A\u2019 out of the MMPI\u20102: on the future assessment of hostility","volume":"13","author":"Mittag","year":"2004","journal-title":"Z Med Psychol"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0110","series-title":"MMPI\u20102. Manual","author":"Hathaway","year":"2000"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0115","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1160\/TH07-07-0448","article-title":"Stability of coagulation assays performed in plasma from citrated whole blood transported at ambient temperature","volume":"99","author":"Z\u00fcrcher","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00001648-199005000-00009","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0125","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/pds.1556","article-title":"Risk factors for nonadherence to warfarin: results from the IN\u2010RANGE study","volume":"17","author":"Platt","year":"2008","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0130","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/CS20040359","article-title":"Different contribution of interleukin\u20106 and cortisol activity to total plasma fibrin concentration and to acute mental stress\u2010induced fibrin formation","volume":"109","author":"von K\u00e4nel","year":"2005","journal-title":"Clin Sci"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0135","unstructured":"Papoulis A. Probability and Statistics. New York: Prentence\u2010Hall International Editions, 1990."},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0140","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00006842-200107000-00003","article-title":"Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease?","volume":"63","author":"von K\u00e4nel","year":"2001","journal-title":"Psychosom Med"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.pcad.2003.09.001","article-title":"Psychosocial factors in the development of coronary artery disease","volume":"46","author":"Strike","year":"2004","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0150","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1538-7836.2007.02857.x","article-title":"Psychosocial factors and venous thromboembolism: a long\u2010term follow\u2010up study of Swedish men","volume":"6","author":"Rosengren","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0155","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1160\/TH11-09-0667","article-title":"Emotional states and future risk of venous thromboembolism. The Troms\u00f8 Study","volume":"107","author":"Enga","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0160","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijcard.2007.06.039","article-title":"Impact of earthquakes on risk for pulmonary embolism","volume":"129","author":"Watanabe","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0165","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1001\/archinte.160.14.2101","article-title":"Depression is a risk factor for noncompliance with medical treatment: meta\u2010analysis of the effects of anxiety and depression on patient adherence","volume":"160","author":"DiMatteo","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0170","first-page":"51","article-title":"Current issues in patient adherence and persistence: focus on anticoagulants for the treatment and prevention of thromboembolism","volume":"4","author":"Kneeland","year":"2010","journal-title":"Patient Prefer Adherence"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0175","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0180","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1017\/S0033291710000267","article-title":"Psychological distress and circulating inflammatory markers in healthy young adults","volume":"40","author":"Goldman\u2010Mellor","year":"2010","journal-title":"Psychol Med"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0185","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.tcm.2005.07.004","article-title":"Two\u2010way interactions between inflammation and coagulation","volume":"15","author":"Levi","year":"2005","journal-title":"Trends Cardiovasc Med"},{"key":"10.1111\/j.1538-7836.2012.04801.x_bb0190","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jpsychores.2011.12.003","article-title":"No further research needed: abandoning the Hospital and Anxiety Depression Scale (HADS)","volume":"72","author":"Coyne","year":"2012","journal-title":"J Psychosom Res"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1538-7836.2012.04801.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622064194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622064194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1538-7836.2012.04801.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:03:15Z","timestamp":1761534195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622064194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1538783622064194"],"URL":"https:\/\/doi.org\/10.1111\/j.1538-7836.2012.04801.x","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relation of psychological distress to the international normalized ratio in patients with venous thromboembolism with and without oral anticoagulant therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1538-7836.2012.04801.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}