{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:19:04Z","timestamp":1790705944163,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":3718,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1111\/j.1538-7836.2012.04872.x","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T05:28:26Z","timestamp":1343626106000},"page":"2039-2044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Risk of post\u2010thrombotic syndrome after subtherapeutic warfarin anticoagulation for a first unprovoked deep vein thrombosis: results from the REVERSE study"],"prefix":"10.1016","volume":"10","author":[{"given":"R.S.","family":"CHITSIKE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"RODGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"KOVACS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"BETANCOURT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"WELLS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"ANDERSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"CHAGNON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"LE GAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"SOLYMOSS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"CROWTHER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"PERRIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.H.","family":"WHITE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.","family":"VICKARS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"RAMSAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"KAHN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0010","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11239-009-0309-3","article-title":"Incidence and cost burden of post\u2010thrombotic syndrome","volume":"28","author":"Ashrani","year":"2009","journal-title":"J Thromb Thrombolysis"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0015","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1538-7836.2008.03002.x","article-title":"Determinants of health\u2010related quality of life during the 2\u2003years following deep vein thrombosis","volume":"6","author":"Kahn","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0020","doi-asserted-by":"crossref","first-page":"454","DOI":"10.7326\/0003-4819-126-6-199703150-00006","article-title":"Cost of long\u2010term complications of deep venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden","volume":"126","author":"Bergqvist","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0025","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1111\/j.1538-7836.2011.04516.x","article-title":"Economic burden and cost determinants of deep vein thrombosis during two years following diagnosis: a prospective evaluation","volume":"9","author":"Guanella","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0030","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1111\/j.1538-7836.2008.03180.x","article-title":"Risk factors for post\u2010thrombotic syndrome in patients with a first deep venous thrombosis","volume":"6","author":"Tick","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0035","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1538-7836.2006.01795.x","article-title":"Post\u2010thrombotic syndrome, recurrence, and death 10\u2003years after the first episode of venous thromboembolism treated with warfarin for 6\u2003weeks or 6\u2003months","volume":"4","author":"Schulman","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0040","doi-asserted-by":"crossref","first-page":"698","DOI":"10.7326\/0003-4819-149-10-200811180-00004","article-title":"Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis","volume":"149","author":"Kahn","year":"2008","journal-title":"Ann Intern Med"},{"issue":"Suppl 4","key":"10.1111\/j.1538-7836.2012.04872.x_bb0045","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S0049-3848(09)70146-X","article-title":"Valvular dysfunction and venous obstruction in the post\u2010thrombotic syndrome","volume":"123","author":"Vedantham","year":"2009","journal-title":"Thromb Res"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0050","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1538-7836.2005.01333.x","article-title":"Relation between quality of anticoagulant treatment and the development of the postthrombotic syndrome","volume":"3","author":"van Dongen","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0049-3848(00)00370-4","article-title":"Post\u2010thrombotic syndrome after primary event of deep venous thrombosis 10 to 20\u2003years ago","volume":"101","author":"Ziegler","year":"2001","journal-title":"Thromb Res"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0060","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"Connolly","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0065","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1007903","article-title":"Oral rivaroxaban for symptomatic venous thromboembolism","volume":"363","author":"Bauersachs","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0070","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1161\/CIRCULATIONAHA.107.750000","article-title":"Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range","volume":"118","author":"Connolly","year":"2008","journal-title":"Circulation"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0075","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJMoa035422","article-title":"Comparison of low\u2010intensity warfarin therapy with conventional\u2010intensity warfarin therapy for long\u2010term prevention of recurrent venous thromboembolism","volume":"349","author":"Kearon","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0080","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1503\/cmaj.080493","article-title":"Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy","volume":"179","author":"Rodger","year":"2008","journal-title":"CMAJ"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0085","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1538-7836.2009.03294.x","article-title":"Definition of post\u2010thrombotic syndrome of the leg for use in clinical investigations: a recommendation for standardization","volume":"7","author":"Kahn","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0090","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1160\/TH07-11-0678","article-title":"Inter\u2010observer reliability of measures to assess the post\u2010thrombotic syndrome","volume":"100","author":"Rodger","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0095","first-page":"158a","article-title":"Assessment of validity and reproducibility of a clinical scale for the post\u2010thrombotic syndrome","volume":"24","author":"Villalta","year":"1994","journal-title":"Haemostasis"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0100","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1055\/s-0038-1651587","article-title":"A method to determine the optimal intensity of oral anticoagulant therapy","volume":"69","author":"Rosendaal","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0105","doi-asserted-by":"crossref","first-page":"e419S","DOI":"10.1378\/chest.11-2301","article-title":"Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence\u2010Based Clinical Practice Guidelines","volume":"141","author":"Kearon","year":"2012","journal-title":"Chest"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004177","article-title":"Compression therapy for treating stage I and II (Widmer) post\u2010thrombotic syndrome","author":"Kolbach","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-125-1-199607010-00001","article-title":"The long\u2010term clinical course of acute deep venous thrombosis","volume":"125","author":"Prandoni","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1111\/j.1538-7836.2012.04872.x_bb0120","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.amjmed.2008.12.023","article-title":"Home therapy of venous thrombosis with long\u2010term LMWH versus usual care: patient satisfaction and post\u2010thrombotic syndrome","volume":"122","author":"Hull","year":"2009","journal-title":"Am J Med"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1538-7836.2012.04872.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622064923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622064923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1538-7836.2012.04872.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:57:44Z","timestamp":1761533864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622064923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S1538783622064923"],"URL":"https:\/\/doi.org\/10.1111\/j.1538-7836.2012.04872.x","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of post\u2010thrombotic syndrome after subtherapeutic warfarin anticoagulation for a first unprovoked deep vein thrombosis: results from the REVERSE study","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1538-7836.2012.04872.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}