{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:44:01Z","timestamp":1771263841378,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T00:00:00Z","timestamp":1138060800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p> <jats:italic>\n            <jats:bold>Background:<\/jats:bold> Rate\u2010responsive pacemakers (PMs) are often supplied with accelerometer (XL) and minute ventilation (MV) sensors to provide a physiologic rate response according to patient needs. No information is available about the real benefit of dual\u2010sensor rate\u2010responsive pacing on the daily life of patients.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Methods:<\/jats:bold> DUSISLOG (Dual Sensor vs Single Sensor comparison using patient activity LOGbook) is a two\u2010arm prospective, randomized, multicenter study that enrolled 105 patients who received a rate\u2010responsive PM (Insignia<\/jats:italic>\n          <jats:sup>\u00ae<\/jats:sup>, <jats:italic>Guidant Corp.). After 1 month of DDD pacing at 60 ppm lower rate, a single sensor (XL or MV, randomized) was activated for 3 months at the manufacturer's suggested nominal settings, followed by a 3\u2010month period with dual sensors optimized with automatic response. During the last month of each period, the following data concerning patient physical activity were retrieved from PM diagnostics (Activity Log): mean percentage of physical activity, mean intensity of activity. Quality of life (QoL) scores and 6\u2010minute walk test (WT) were also recorded.<\/jats:italic><\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Results:<\/jats:bold> Single\u2010sensor rate\u2010responsive pacing resulted in symptomatic benefit equally with XL and MV sensors while no additional benefit was found using dual sensor. In a subgroup analysis, patients (17%) with marked chronotropic incompetence and with 0% atrial sensing received benefits from single sensor with an additional advantage from sensor (QoL: +21 \u00b1 14% P &lt; 0.05; WT: +17 \u00b1 7% P &lt; 0.02).<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Conclusion:<\/jats:bold> In most patients with rate\u2010responsive devices, a single sensor is sufficient to achieve a satisfactory rate response. A dual sensor combination and optimization provides an additional benefit only in a selected population with an advanced atrial chronotropic disease.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-8159.2006.00301.x","type":"journal-article","created":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T10:41:21Z","timestamp":1138099281000},"page":"34-40","source":"Crossref","is-referenced-by-count":39,"title":["Is a Dual\u2010Sensor Pacemaker Appropriate in Patients with Sino\u2010Atrial Disease? 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