{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:21:03Z","timestamp":1772004063976,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T00:00:00Z","timestamp":1146787200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p> <jats:italic>\n            <jats:bold>Background:<\/jats:bold> Altered cardiac autonomic control may play a role in the morbidity and mortality suffered by neonates who undergo surgery for complex congenital heart disease (CHD). The purpose of this study was to evaluate cardiac autonomic activity, as measured by spectral indices of heart rate variability (HRV), prior to and early after infant surgery for CHD and attempt to correlate HRV indices with clinical outcome. In addition, we assessed the hypothesis that single\u2010ventricle physiology and surgical interruption of the great arteries negatively affects HRV.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Methods:<\/jats:bold> Sixty neonates prospectively wore 24\u2010hour Holter monitors at three time points: before and early after CHD surgery, and at 3\u2010 to 6\u2010month follow\u2010up. Standard spectral indices of HRV were measured.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Results:<\/jats:bold> In the early postoperative time point, patients with single\u2010ventricle physiology had lower low\u2010frequency power (LF) compared to patients with two ventricles (P = 0.040). Surgical interruption of the great arteries did not affect HRV in this cohort. For the entire cohort, LF (P = 0.004) and high\u2010frequency power (HF) (P &lt; 0.001) increased over the three time points, while LF\/HF (P = 0.119) did not significantly change. In the multivariable linear regression model, significant predictors of longer postoperative hospital stay included longer total support time (P = &lt; 0.001), longer duration of inotrope support (P = 0.012), elevated mean heart rate at postoperative time point (P = 0.002), and lower LF\/HF ratio at the postoperative time point (P = 0.014).<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Conclusion:<\/jats:bold> Patients with single\u2010ventricle physiology have a significant physiologic reduction in LF in the early postoperative period compared to patients with two ventricles. Diminished cardiac autonomic control is associated with longer hospitalization following neonatal cardiac surgery.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-8159.2006.00378.x","type":"journal-article","created":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T09:27:30Z","timestamp":1146821250000},"page":"471-478","source":"Crossref","is-referenced-by-count":17,"title":["Heart Rate Variability Following Neonatal Heart Surgery for Complex Congenital Heart Disease"],"prefix":"10.1111","volume":"29","author":[{"given":"JONATHAN R.","family":"KALTMAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRIAN D.","family":"HANNA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL R.","family":"GALLAGHER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. WILLIAM","family":"GAYNOR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RODOLFO I.","family":"GODINEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RONN E.","family":"TANEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAULLY J.","family":"SHAH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VICTORIA L.","family":"VETTER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LARRY A.","family":"RHODES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.suppl_3.III-136"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"I\u201082","DOI":"10.1161\/01.cir.0000032878.55215.bd","article-title":"Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: Lessons learned from 115 consecutive patients","volume":"106","author":"Tweddell JS","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_7_4_2","article-title":"Risk factors for interstage death after the Norwood procedure","author":"Simsic JM","journal-title":"Pediatr Cardiol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)02324-9"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00168-1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02795-3"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00313-5"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11144-8"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047275.25795.17"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.6.704"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.096326"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"II\u2010180","DOI":"10.1161\/01.cir.0000087946.47069.cb","article-title":"Global impairment of cardiac autonomic nervous activity late after Fontan operation","volume":"108","author":"Davos CH","year":"2003","journal-title":"Circulation"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb00158.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.suppl_2.II-182"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900178"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000014220"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050979"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.6.1449"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.6.556"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1875"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02083703"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8159.2006.00378.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8159.2006.00378.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T11:29:08Z","timestamp":1697282948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8159.2006.00378.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1540-8159.2006.00378.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8159.2006.00378.x","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}