{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:46:44Z","timestamp":1697176004839},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p> <jats:italic>\n            <jats:bold>Aim:<\/jats:bold> High heart rates in chronic atrial fibrillation (CAF) is one of the factors responsible for hemodynamic alterations and may lead to tachycardiomyopathies. The ventricular rate regulation (VRR) study evaluates the effect of ventricular rate regularization in CAF patients with preserved ventricular function, marked ventricular rate variability, and indications for pacemaker (PM) implantation owing to symptomatic pauses. Rate regularization was achieved using VRR algorithm (INSIGNIA\u00ae pacemakers, Guidant Corp., St. Paul, MN, USA)<\/jats:italic>.<\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Methods:<\/jats:bold> One month after PM implantation, 58 patients followed two 3\u2010month crossover periods (VRR\u2010OFF; VRR\u2010ON) in which the VRR algorithm was randomized and compared to fixed rate stimulation at 60 ppm. During follow\u2010up visits a 6\u2010minute walk test was performed under partially inhibited conditions (PM at 40 ppm) and ventricular response was recorded. The following parameters were measured: mean ventricular rate (MR), rate variability (RR30), rate recovery after exercise (SLOPE = (R\u2010END \u2013 R\u2010REC)\/(R\u2010END \u2013 40)), R\u2010END being the rate at end of walk and R\u2010REC the rate 1 minute after exercise.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Results:<\/jats:bold> The VRR algorithm decreased rate variability (RR30: \u22127.36 \u00b1 8.8; P &lt; 0.01) without increasing ventricular rate (MR: \u22121.11 \u00b1 8.3 P = NS), while SLOPE improved significantly (SLOPE: +15.41 \u00b1 16.8 P &lt; 0.01).<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Conclusions:<\/jats:bold> VRR effectively stabilizes rate, without increasing pacing rate above spontaneous rhythm and helps achieve a more favorable autonomic balance, improving rate recovery after exercise.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-8159.2006.00453.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T10:07:22Z","timestamp":1155550042000},"page":"866-874","source":"Crossref","is-referenced-by-count":11,"title":["Role of Rate Control and Regularization Through Pacing in Patients With Chronic Atrial Fibrillation and Preserved Ventricular Function: The VRR Study"],"prefix":"10.1111","volume":"29","author":[{"given":"GIANFRANCO","family":"CIARAMITARO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIUSEPPE","family":"SGARITO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANCESCO","family":"SOLIMENE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIANPIERO","family":"MAGLIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALFREDO","family":"VICENTINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIOVANNI","family":"DI DONATO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIOVANNI","family":"RACITI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIOVANNI","family":"PARRINELLO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIOVANNI BATTISTA","family":"DEL GIUDICE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1161\/circ.104.17.2118","article-title":"ACC\/AHA\/ESC guidelines for the management of patients with atrial fibrillation: Executive summary. 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