{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T18:14:07Z","timestamp":1774289647260,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T00:00:00Z","timestamp":1303084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p> <jats:italic>\n            <jats:bold>Background:<\/jats:bold> Catheter ablation of complex fractionated atrial electrograms (CFAE) for persistent atrial fibrillation (AF) is a promising treatment strategy. We tested the hypothesis that CFAE ablation is superior to linear ablation in patients with persistent or long\u2010standing persistent AF.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Methods:<\/jats:bold> In this study, 116 patients with persistent AF were randomly assigned to undergo circumferential PVI plus additional lines (linear ablation group; 59 patients) or CFAE ablation plus ostial pulmonary vein isolation (PVI) (spot ablation group; 57 patients). Primary endpoint was freedom from atrial tachyarrhythmia after a single ablation procedure (clinical and repeat 7\u2010day Holter), 12 months after ablation without antiarrhythmic medication.<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Results:<\/jats:bold> The primary endpoint was reached in 22 of 59 (37%) patients of the linear ablation group and in 22 of 57 (39%) patients of the spot ablation group (P = 0.9). Freedom from atrial tachyarrhythmias, including reablations, was achieved in 54% of patients (linear ablation group) versus 56% of patients (spot ablation group; P = 0.8). The incidence of recurrent persistent AF was higher after linear ablation than after spot ablation (21\/37 vs 11\/35 patients; P = 0.03); atrial tachycardia (AT) was seen more often after spot ablation (10\/35 vs 4\/37 patients; P = 0.03).<\/jats:italic> <\/jats:p><jats:p> <jats:italic>\n            <jats:bold>Conclusion:<\/jats:bold> In patients with persistent AF, CFAE ablation plus PVI reaches the same results as circumferential PVI plus lines, in terms of freedom from symptomatic atrial tachyarrhythmias within the first year after a single ablation procedure. Arrhythmia recurrences in patients after spot ablation were caused more often by AT, whereas recurrent persistent AF was more prevalent after the linear ablation approach. (PACE 2011; 34:939\u2013948)<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1540-8159.2011.03100.x","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T19:52:24Z","timestamp":1303156344000},"page":"939-948","source":"Crossref","is-referenced-by-count":36,"title":["Complex Fractionated Atrial Electrogram or Linear Ablation in Patients with Persistent Atrial Fibrillation\u2014A Prospective Randomized Study"],"prefix":"10.1111","volume":"34","author":[{"given":"HEIDI 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