{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:58:40Z","timestamp":1769108320252,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T00:00:00Z","timestamp":1311811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Objective:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>To determine the prevalence and the prognostic value of exercise\u2010induced ventricular arrhythmia (EIVA) in chronic Chagas\u2019 heart disease.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Study Design and Setting:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>An open prospective cohort of 130 clinically stable patients at a University Hospital outpatient unit in Rio de Janeiro, Brazil, was followed up at scheduled clinical visits from 1990 through 2007. The endpoint was total cardiovascular mortality. Survival curves (Kaplan\u2010Meier) and a multivariate Cox proportional hazard model were adjusted to determine the association between EIVA and mortality.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>The median duration of follow\u2010up was 9.9 years (range, 132 days to 17 years). EIVA prevalence was 43.1% (95% CI: 34.5\u201351.7)<\/jats:italic>. <jats:italic>Thirty\u2010three cardiovascular deaths (25.4%) occurred. The hazard ratio of EIVA for cardiovascular death, after adjustment for age, was 1.84 (P = 0.09). An interaction was found between EIVA and cardiomegaly on x\u2010ray. In the group with cardiomegaly, the hazard of dying was four times greater in the presence of EIVA (P for interaction = 0.05).<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>In clinically stable chagasic subjects with cardiomegaly, EIVA is a clinically significant marker of total cardiovascular mortality and may be a useful risk stratification tool in this population. (PACE 2011; 34:1492\u20131497)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8159.2011.03171.x","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T19:09:22Z","timestamp":1311880162000},"page":"1492-1497","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic Value of Exercise\u2010Induced Ventricular Arrhythmia in Chagas\u2019 Heart Disease"],"prefix":"10.1111","volume":"34","author":[{"given":"ROBERTO COURY","family":"PEDROSA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOS\u00c9 HUGO GAMEIRO","family":"SALLES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MONICA M. 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