{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:04:49Z","timestamp":1778223889062,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T00:00:00Z","timestamp":1311811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p><jats:italic>\n            <jats:bold>Background:<\/jats:bold> To evaluate the acute hemodynamic effects of different right (RV) and left ventricular (LV) pacing sites in patients undergoing the implantation of a cardiac resynchronization therapy defibrillator (CRT\u2010D).<\/jats:italic><\/jats:p><jats:p><jats:italic>\n            <jats:bold>Methods:<\/jats:bold> Stroke volume index (SVI), assessed via pulse contour analysis, and dp\/dt max, obtained in the abdominal aorta, were analyzed in 21 patients with New York Heart Association class III heart failure and left bundle branch block (mean ejection fraction of 24 \u00b1 6%), scheduled for CRT\u2010D implantation under general anesthesia. We compared the hemodynamic effects of RV apical (A), RV septal (B), and biventricular pacing using the worst (lowest SVI; C) and best (highest SVI; D) coronary sinus lead positions.<\/jats:italic><\/jats:p><jats:p><jats:italic>\n            <jats:bold>Results:<\/jats:bold> Mean arterial pressure, SVI, and dp\/dt max did not differ significantly between RV apical and septal pacing. Dp\/dt max and SVI increased significantly during biventricular pacing (dp\/dt max: B, 588 \u00b1 160 mmHg\/s; C, 651 \u00b1 218 mmHg\/s, P = 0.03 vs B; D, 690 \u00b1 220 mmHg\/s, P = 0.02 vs C; SVI: B, 33.6 \u00b1 5.5 mL\/m<jats:sup>2<\/jats:sup>, C, 34.8 \u00b1 6.1 mL\/m<jats:sup>2<\/jats:sup>, P = 0.08 vs B, D 36.0 \u00b1 6.0 mL\/m<jats:sup>2<\/jats:sup>, P &lt; 0.001 vs C). The best hemodynamic response was associated with lateral or inferior lead positions in 15 patients. Other LV lead positions were most effective in six patients.<\/jats:italic><\/jats:p><jats:p><jats:italic>\n            <jats:bold>Conclusions:<\/jats:bold> The optimal LV lead position varies significantly among patients and should be individually determined during CRT\u2010D implantation. The impact of the RV stimulation site in patients with intraventricular conduction delay, undergoing CRT\u2010D implantation, has to be investigated in further studies. 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