{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:31:44Z","timestamp":1792812704922,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,6]],"date-time":"2011-11-06T00:00:00Z","timestamp":1320537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Background:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>The combination of intravenous propofol and midazolam is frequently used to provide unconscious sedation during catheter ablation of atrial fibrillation (AF), but only a very few reports are available on the influence of prolonged propofol infusion on arterial blood gas, blood pressure, and anesthesia\u2010associated complications during ablation of AF. The purpose of this study was to assess tolerance and safety of unconscious sedation with intravenous propofol and midazolam during catheter ablation of AF.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>A total of 316 consecutive patients (age 59 \u00b1 10 years, 68% men) presenting to our center for catheter ablation of symptomatic AF were enrolled prospectively. A total number of 424 procedures were performed under unconscious sedation with propofol and midazolam. SaO<jats:sub>2<\/jats:sub>, electrocardiogram, arterial blood pressure, and arterial blood gases were monitored throughout the procedure.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>Mean procedure duration was 235 \u00b1 48 minutes. Patients received 1.125 \u00b1 684 mg propofol, 9.5 \u00b1 3 midazolam, and 1.963 \u00b1 813 mL NaCl infusion. Complications during the procedure were identified in eight patients (2.5%, one \u00d7 coronary air embolization, one \u00d7 myocardial infarction, four \u00d7 pericardial effusion, two \u00d7 pericardial tamponade). All eight patients were symptomatic (distress, report of pain); none of the complications was attributable to unconscious sedation itself.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>Unconscious sedation with propofol and midazolam in AF ablation procedures lasting 3\u20135 hours did not result in severe changes of vital parameters or serum electrolytes. Anesthesia\u2010associated problems were not observed. Propofol and midazolam can be safely used during catheter ablation of AF. 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