{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:05:11Z","timestamp":1789034711910,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Aims:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>SafeR performance versus DDD\/automatic mode conversion (DDD\/AMC) and DDD with a 250\u2010ms atrioventricular (AV) delay (DDD\/LD) modes was assessed toward ventricular pacing (Vp) reduction<\/jats:italic>.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>After a 1\u2010month run\u2010in phase, recipients of dual\u2010chamber pacemakers without persistent AV block and persistent atrial fibrillation (AF) were randomly assigned to SafeR, DDD\/AMC, or DDD\/LD in a 1:1:1 design. The main endpoint was the percentage of Vp (%Vp) at 2 months and 1 year after randomization, ascertained from device memories. Secondary endpoints include %Vp at 1 year according to pacing indication and 1\u2010year AF incidence based on automatic mode switch device stored episodes<\/jats:italic>.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>Among 422 randomized patients (73.2 \u00b1 10.6 years, 50% men, sinus node dysfunction 47.4%, paroxysmal AV block 30.3%, bradycardia\u2010tachycardia syndrome 21.8%), 141 were assigned to SafeR versus 146 to DDD\/AMC and 135 to DDD\/LD modes. Mean %Vp at 2 months was 3.4 \u00b1 12.6% in SafeR versus 33.6 \u00b1 34.7% and 14.0 \u00b1 26.0% in DDD\/AMC and DDD\/LD modes, respectively (P &lt; 0.0001 for both). At 1 year, mean %Vp in SafeR was 4.5 \u00b1 15.3% versus 37.9 \u00b1 34.4% and 16.7 \u00b1 28.0% in DDD\/AMC and DDD\/LD modes, respectively (P &lt; 0.0001 for both). The proportion of patients in whom Vp was completely eliminated was significantly higher in SafeR (69%) versus DDD\/AMC (15%) and DDD\/LD (45%) modes (P &lt; 0.0001 for both), regardless of pacing indication. The absolute risk of developing permanent AF or of remaining in AF for &gt;30% of the time was 5.4% lower in SafeR than in the DDD pacing group (ns)<\/jats:italic>.<\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusions:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>In this selected patient population, SafeR markedly suppressed unnecessary Vp compared with DDD modes. PACE 2012; 35:392\u2013402)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8159.2011.03314.x","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T03:55:33Z","timestamp":1328586933000},"page":"392-402","source":"Crossref","is-referenced-by-count":25,"title":["Near Elimination of Ventricular Pacing in SafeR Mode Compared to DDD Modes: A Randomized Study of 422 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