{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:32Z","timestamp":1769385632841,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:00:00Z","timestamp":1331856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Background:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>The goal of this study was to analyze impact of metabolic syndrome (MetS) and impaired renal function on long\u2010term follow\u2010up after catheter ablation of atrial fibrillation (AF).<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods and Results:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>A total of 702 consecutive patients with AF (age = 58 year, history of AF = 5 year, male = 478, paroxysmal atrial fibrillation = 416, coronary artery disease = 62, hypertension = 487) considered for catheter ablation were enrolled in the study. The MetS was diagnosed at admission in 276 patients. The renal function was estimated by glomerular filtration rate (eGFR). Pulmonary vein isolation (PVI) was performed either with cryoballoon technique (n = 260) or circumferential PVI (n = 442) with a 3.5\u2010mm irrigated tip catheter. A 7\u2010day\u2010Holter electrocardiogram was performed at each follow\u2010up visit. Any episode of documented AF after an initial 3\u2010month blanking period was considered as clinical endpoint. Out of 702 patients, 370 (52.7%) were free of AF recurrences at median follow\u2010up of 15 six interquartile range (12.7\u201342.3) months. The patients with MetS had significantly lower success rate than those without (128\/276 (46.4%) vs 242\/426 (56.8%), P = 0.006). Among 103 patients with eGFR &lt; 68 mL\/min only 35 (34%) were free of recurrences compared with 335\/599 (55.9%) in patients with GFR \u2265 68 mL\/min (P = 0.001). Both parameters were revealed in multivariate analysis to be independent predictors for outcome after catheter ablation.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>The results of our study clearly demonstrated that outcome after 1st catheter ablation of AF is poor in patients with MetS and\/or impaired renal function. This observation has a potential clinical impact for the follow up management of these patients. (PACE 2012;1\u201312)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8159.2012.03350.x","type":"journal-article","created":{"date-parts":[[2012,3,17]],"date-time":"2012-03-17T01:23:07Z","timestamp":1331947387000},"page":"532-543","source":"Crossref","is-referenced-by-count":37,"title":["Impact of Impaired Renal Function and Metabolic Syndrome on the Recurrence of Atrial Fibrillation after Catheter Ablation: A Long Term 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