{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:25:52Z","timestamp":1790965552301,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,3,4]],"date-time":"2012-03-04T00:00:00Z","timestamp":1330819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Background:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>Patients with myotonic dystrophy (DM) have an annual mortality of approximately 3.5%, one\u2010third of which is sudden cardiac death. The predictors of cardiac conduction disease in these patients are incompletely defined.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>A single\u2010center cohort study included 211 patients with DM type 1 (DM1) and 25 DM type 2 (DM2). A severe electrocardiogram (ECG) abnormality was defined as a PR interval of \u2265240 ms or QRS duration of \u2265120 ms.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>A severe ECG abnormality was found in 24% of DM1 patients and 17% of DM2 patients. Among DM1 patients, those with a severe ECG abnormality were older (41.6 \u00b1 14.6 vs 35.4 \u00b1 12.6 years) and more likely to have hypertension (13.2% vs 4.2%, P = 0.038), heart failure (4.4% vs 0%, P = 0.056), atrial arrhythmias (6.6% vs 0.7%, P &lt; 0.001), a higher number of trinucleotide repeats (689 \u00b1 451 vs 474 \u00b1 322, P = 0.01), and a family history of sudden cardiac death (26.7% vs 5.6%, P &lt; 0.001) or pacemaker implantation (20% vs 0.7%, P &lt; 0.001). Pacemakers or defibrillators were implanted in 14% of all patients, including 65% of patients with severe ECG abnormalities. During 57 \u00b1 46 months, 13 patients died (1.16% per year), including three patients who died suddenly, two of whom had normally functioning pacemakers.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusion:<\/jats:italic>\n          <\/jats:bold>\u2002<jats:italic>In DM1, atrio\u2010ventricular conduction disease is associated with increasing age, concomitant cardiovascular disease, nucleotide repeat length, and family history. The systematic identification of conduction disease and aggressive use of prophylactic pacemakers is associated with low rate of sudden cardiac death. (PACE 2012; 35:1262\u20131269)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8159.2012.03351.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T20:50:22Z","timestamp":1330980622000},"page":"1262-1269","source":"Crossref","is-referenced-by-count":53,"title":["Predictors of Atrio\u2010Ventricular Conduction Disease, Long\u2010Term Outcomes in Patients with Myotonic Dystrophy Types I and II"],"prefix":"10.1111","volume":"35","author":[{"given":"ANDREW H.","family":"HA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARK A.","family":"TARNOPOLSKY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. GRAHAM","family":"BERGSTRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GIRISH M.","family":"NAIR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ATIF","family":"AL\u2010QUBBANY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEFF S.","family":"HEALEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,4]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-002-0074-6"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142905.hg0906s61"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/BC20100040"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062800"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.8.1658"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.8.1041"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.8.1557"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc081492"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02339-2"},{"key":"e_1_2_7_11_2","first-page":"1626","article-title":"Sudden death in myotonic dystrophy","volume":"359","author":"Hermans MCE","year":"2010","journal-title":"N Engl J Med"},{"key":"e_1_2_7_12_2","first-page":"e350\u2013e408","article-title":"ACC\/AHA\/HRS 2008 Guidelines for Device\u2010Based Therapy of Cardiac Rhythm Abnormalities: A report of the American College of Cardiology\/ American Heart Association Task Force on Practice Guidlines (Writing Committee to Revise the ACC\/AHA\/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhy mia devices): Developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons","volume":"117","author":"Epstein AE","year":"2008","journal-title":"Circulation"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70479-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.3.457"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.4.411"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00351-P"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2010.02905.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-002-0692-6"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp570"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1978.tb14919.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421902"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421902"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8159.2012.03351.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8159.2012.03351.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:42:15Z","timestamp":1698655335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8159.2012.03351.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,4]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1540-8159.2012.03351.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8159.2012.03351.x","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,4]]}}}