{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:31:51Z","timestamp":1770219111486,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,4,29]],"date-time":"2012-04-29T00:00:00Z","timestamp":1335657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>\n            <jats:italic>Background<\/jats:italic>\n          <\/jats:bold>: <jats:italic>The acute effects of right ventricular apical (RVA) pacing on left atrial (LA) function in patients with normal ejection fraction are not clear.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Methods<\/jats:italic>\n          <\/jats:bold>: <jats:italic>A total of 94 patients (age 68.1 \u00b1 11.1 years, 26 men) with implanted RVA\u2010based dual\u2010chamber pacemakers were recruited into this study. Patients who were pacemaker\u2010dependent, in persistent atrial fibrillation or left ventricular ejection fraction &lt;45% were excluded. Echocardiography (iE33, Philips, Andover, MA, USA) was performed during intrinsic ventricular conduction (V\u2010sense) and RVA pacing (V\u2010pace) with 15 minutes between switching modes. The total maximal LA volume (LAV<jats:sub>max<\/jats:sub>), preatrial contraction volume (LAV<jats:sub>pre<\/jats:sub>), and minimal volume (LAV<jats:sub>min<\/jats:sub>) were assessed by area\u2010length method. Peak systolic, early diastolic, and peak late diastolic (atrial contractile) velocity (Sm\u2010la, Em\u2010la, and Am\u2010la) and strain (\u025bs\u2010la, \u025be\u2010la, and \u025ba\u2010la) were measured by color\u2010coded tissue Doppler imaging (TDI) in four mid\u2010LA walls at apical four\u2010 and two\u2010chamber views.<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Results<\/jats:italic>\n          <\/jats:bold>: <jats:italic>During V\u2010pace, LA volumes increased significantly compared with V\u2010sense (LAV<jats:sub>max<\/jats:sub>: 52.0 \u00b1 18.8 vs 55.2 \u00b1 21.1 mL, P = 0.005; LAV<jats:sub>pre<\/jats:sub>: 39.8 \u00b1 16.4 vs 41.3 \u00b1 16.6 mL, P = 0.014; LAV<jats:sub>min<\/jats:sub>: 27.4 \u00b1 14.0 vs 29.1 \u00b1 15.1 mL, P = 0.001). TDI parameters showed significant reduction in Sm\u2010la and Em\u2010la. Furthermore, \u025bs\u2010la, \u025be\u2010la, and \u025ba\u2010la decreased significantly, especially in patients with preexisting diastolic dysfunction (all P &lt; 0.01).<\/jats:italic><\/jats:p><jats:p><jats:bold>\n            <jats:italic>Conclusions:<\/jats:italic>\n          <\/jats:bold>\n          <jats:italic>RVA pacing acutely induced LA enlargement and impaired atrial contractility. Patients with preexisting diastolic dysfunction may be more vulnerable to develop LA dysfunction and remodeling after acute RVA pacing. (PACE 2011;XX:1\u20137)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8159.2012.03403.x","type":"journal-article","created":{"date-parts":[[2012,4,29]],"date-time":"2012-04-29T18:40:28Z","timestamp":1335724828000},"page":"856-862","source":"Crossref","is-referenced-by-count":14,"title":["Acute Effects of Right Ventricular Apical Pacing on Left Atrial Remodeling and Function"],"prefix":"10.1111","volume":"35","author":[{"given":"JUN\u2010MIN","family":"XIE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FANG","family":"FANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QING","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN E.","family":"SANDERSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSEPH","family":"YAT\u2010SUN CHAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YAT\u2010YIN","family":"LAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHEUK\u2010MAN","family":"YU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.814608"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.09.027"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.06.011"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.006"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.05.001"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun237"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014753"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.15.1788"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03625.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.062"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.05.031"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.12.075"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.073"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072769.17295.B1"},{"key":"e_1_2_7_16_2","first-page":"151","article-title":"The effects of short time right ventricular pacing on left atrial mechanical functions","volume":"9","author":"Gulmez O","year":"2009","journal-title":"Indian Pacing Electrophysiol J"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup322"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02061.x"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8159.2012.03403.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8159.2012.03403.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:42:25Z","timestamp":1698651745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8159.2012.03403.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,29]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1540-8159.2012.03403.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8159.2012.03403.x","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,29]]}}}