{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T11:20:55Z","timestamp":1769340055495,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T00:00:00Z","timestamp":1342828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:italic>\n            <jats:bold>Background:<\/jats:bold> Radiofrequency ablation of typical atrial flutter is largely used and is considered as safe. The purpose of the study was to evaluate the prevalence and the causes of severe adverse event (AE) following atrial flutter ablation.<\/jats:italic><\/jats:p><jats:p><jats:italic>\n            <jats:bold>Methods:<\/jats:bold> Ablation of typical flutter was performed by conventional method with an 8\u2010mm\u2010tip electrode catheter, a maximum power of 70 W, and a maximum target temperature of 70\u00b0 for 60 seconds in 883 patients, (685 males and 198 females aged from 18 to 93 years [64 \u00b1 11.5]; 664 had heart disease [HD]).<\/jats:italic><\/jats:p><jats:p><jats:italic>\n            <jats:bold>Results:<\/jats:bold> AE occurred in 44 patients (5%). AE was life threatening in 14 patients: poorly tolerated bradycardia (transient complete atrioventricular block [AVB] or sinus bradycardia [SB] &lt;40 beats per minute) associated with cardiac shock and acute renal failure in five patients, tamponade (n = 1), bleeding leading to death (n = 1), various AE\u2010related deaths (n = 2), ventricular tachycardia\u2010related death (n = 1), definitive complete AVB (n = 3), and right coronary artery occlusion\u2010related complete AVB (n = 1). Less serious AE occurred in 30 patients: transitory major SB or second\u2010 or third\u2010degree AVB (n = 23), bleeding (n = 4), transient ischemic attack (n = 1), and various AE (n = 2). Most of the bradycardia was related to \u03b2\u2010blockers or other antiarrhythmic drugs used to slow atrial flutter. Factors of AE were female gender (36% vs 22%, P &lt; 0.02) and the presence of ischemic (P &lt; 0.03) or valvular HD (P &lt; 0.01).<\/jats:italic><\/jats:p><jats:p><jats:italic>\n            <jats:bold>Conclusions:<\/jats:bold> AE following atrial flutter ablation occurred in 5% of patients. Most of them are avoidable by control of anticoagulants and arrest of rate\u2010control drugs used to slow the rate of atrial flutter. 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