{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:10:02Z","timestamp":1758399002986},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T00:00:00Z","timestamp":1342828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:italic>\n            <jats:bold>Background:<\/jats:bold> Concealed sick sinus syndrome may become manifest after restoration of sinus rhythm by ablation in patients with long\u2010standing persistent atrial fibrillation (AF). The purpose of this study was to investigate the association between the preprocedural ventricular rate during AF and sinus node function in patients with long\u2010standing persistent AF<\/jats:italic>.<\/jats:p><jats:p><jats:italic>\n            <jats:bold>Methods:<\/jats:bold> Consecutive patients (n = 102) who underwent ablation for long\u2010standing persistent AF were enrolled. We measured the ventricular rate during AF before ablation in the absence of antiarrhythmic drugs. Sinus node function was assessed by electrophysiological study and serial Holter recordings after ablation.<\/jats:italic><\/jats:p><jats:p><jats:italic>\n            <jats:bold>Results:<\/jats:bold> Patients in the lowest quartile of ventricular rate during AF had longer corrected sinus node recovery time (1.06 \u00b1 1.39 seconds) than those in the other quartiles (0.54 \u00b1 0.31 seconds; P = 0.006) and lower mean heart rate on 24\u2010hour Holter recording 3 months after ablation (68 \u00b1 9 beats\/min vs 75 \u00b1 10 beats\/min, P = 0.01). During a mean follow\u2010up of 23 \u00b1 10 months, sick sinus syndrome necessitating permanent pacemaker implantation developed in five (5%) patients, and multivariate analysis revealed that a low ventricular rate during AF rate was an independent risk factor for sick sinus syndrome (odds ratio = 0.90 for a 1 beat\/min increase in AF rate, P = 0.04).<\/jats:italic><\/jats:p><jats:p><jats:italic>\n            <jats:bold>Conclusions:<\/jats:bold> A low preprocedural ventricular rate during AF indicates the existence of sinus node dysfunction after restoration of sinus rhythm by ablation in patients with long\u2010standing persistent AF. (PACE 2012; 35:1074\u20131080)<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1540-8159.2012.03477.x","type":"journal-article","created":{"date-parts":[[2012,7,22]],"date-time":"2012-07-22T02:47:56Z","timestamp":1342925276000},"page":"1074-1080","source":"Crossref","is-referenced-by-count":6,"title":["Preprocedural Ventricular Rate Predicts Subsequent Sick Sinus Syndrome after Ablation for Long\u2010Standing Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"35","author":[{"given":"MASAHARU","family":"MASUDA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KOICHI","family":"INOUE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATSUOMI","family":"IWAKURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ATSUNORI","family":"OKAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YASUSHI","family":"KOYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RYUSUKE","family":"KIMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUKO","family":"TOYOSHIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ATSUSHI","family":"DOI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOHEI","family":"SOTOMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ISSEI","family":"KOMURO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KENSHI","family":"FUJII","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.01.017"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.4.1662"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1001\/jama.1968.03150030101028","article-title":"The SSS in atrial disease","volume":"206","author":"Ferrer MI","year":"1968","journal-title":"JAMA"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.63.1.80"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(77)80070-7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.2953"},{"key":"e_1_2_6_8_2","first-page":"383","article-title":"Impaired sinus node function and global atrial conduction time after high rate atrial pacing in dogs","volume":"7","author":"Zupan I","year":"2002","journal-title":"Cell Mol Biol Lett"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000090685.13169.07"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00800.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.43.6.836"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90619-0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2005.04.006"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8159.2012.03477.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8159.2012.03477.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T18:23:23Z","timestamp":1697653403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8159.2012.03477.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,21]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1540-8159.2012.03477.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8159.2012.03477.x","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,21]]}}}