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The metabolites retain sodium channel blocking activity but little \u03b2\u2010adrenergic blocking activity. Both controlled and noncontrolled studies have documented its efficacy in a variety of supraventricluar arrhythmias. Intravenous propafenone is effective in converting atrial fibrillation to normal sinus rhythm. Chronic oral administration decreases the frequency of recurrence of atrial fibrillation and paroxysmal supraventricular tachycardia. The drug is particularly effective in the Wolff\u2010Parkinson\u2010White syndrome. The drug may produce SA block in patients with underlying sinus node dysfunction. Propafenone has comparatively few noncardiac side effects. 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