{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:49:31Z","timestamp":1779223771615,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":3702,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>The Brugada Syndrome. In 1992, Brugada and Brugada described a syndrome characterized by right bundle branch block pattern with ST elevation in leads V<jats:sub>1<\/jats:sub> through V<jats:sub>3<\/jats:sub> and a history of sudden death due to polymorphic ventricular tachycardia or ventricular fibrillation. Since these patients bad no evidence of cardiac disease, these findings were ascribed to a distinct clinical entity. Further experience bas shown that this same pattern may be mimicked by patients with right ventricular dysplasia, acute ischemia of the right ventricle, other infiltrative cardiomyopathies, as well as tricyclic drug overdose. The pathogenesis of these changes may be due to loss of the dome configuration in the transmembrane potential of right ventricular epicardial cells, which would result in a voltage gradient producing ST elevation. Other explanations involve delayed conduction in a dysplastic right ventricle. The clinical importance of this syndrome is that it calls attention to patients at risk for sudden cardiac death. In addition, these observations have sparked the interest of basic electrophysiologists relative to the relationship of these ECG waveforms and malignant ventricular arrhythmias. Finally, the clinician must exclude other organic diseases before diagnosing this entity.<\/jats:p>","DOI":"10.1111\/j.1540-8167.1997.tb00797.x","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T15:14:11Z","timestamp":1177082051000},"page":"332-336","source":"Crossref","is-referenced-by-count":34,"title":["Is the Brugada Syndrome a Distinct Clinical Entity?"],"prefix":"10.1111","volume":"8","author":[{"given":"MELVIN M.","family":"SCHEINMAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.4.809"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90626-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/6.suppl_D.115"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80654-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90253-J"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90011-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90070-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.5.1294"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00613-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00485-8"},{"key":"e_1_2_1_12_2","first-page":"669","article-title":"Right bundle branch block, persistent right precordial ST segment elevation, and sudden arrhythmic death in young people","volume":"19","author":"Corrado D","year":"1996","journal-title":"PACE"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90142-9"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.42.5.603"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.47.2.151"},{"key":"e_1_2_1_16_2","first-page":"88","volume-title":"Cardiac Arrhythmia: Mechanism, Diagnosis and Management","author":"Antzelevitch C","year":"1995"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.2.372"},{"key":"e_1_2_1_18_2","first-page":"233","volume-title":"Cardiac Arrhythmias: From Diagnosis to Therapy","author":"Fontaine G","year":"1984"},{"key":"e_1_2_1_19_2","first-page":"228","volume-title":"Cardiac Electrophysiology: From Cell to Bedside","author":"Antzelevitch C","year":"1994"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90529-0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/10.suppl_E.2"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.4.1839"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.2.277"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.1997.tb00797.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.1997.tb00797.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T20:02:46Z","timestamp":1698436966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.1997.tb00797.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["10.1111\/j.1540-8167.1997.tb00797.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.1997.tb00797.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}