{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:57:17Z","timestamp":1758477437758},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T00:00:00Z","timestamp":1180051200000},"content-version":"vor","delay-in-days":3615,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>Neonatal Long QT Syndrome. <jats:italic>Introduction<\/jats:italic>: The neonatal presentation of the long QT syndrome is rare, although it is frequently accompanied by life\u2010threatening arrhythmias. Infants may not survive childhood despite traditional management with beta\u2010adrenergic blockade and pacing.<\/jats:p><jats:p> <jats:italic>Methods and Results<\/jats:italic>: This case describes a newborn with a long QT interval, T wave alternans, intermittent 2:1 AV block, ventricular arrhythmias, and a family history of sudden death. After failing medical therapy, conventional VVI and DDD pacing were unsuccessful due to prolonged ventricular refractoriness and proarrhythmia. At 2 months of life, the child was treated with high\u2010rate (180 ppm) atrial pacing to produce intentional 2:1 AV block. Following an episode of possible syncope at 16 months of age, an automatic implantable cardioverter defibrillator (ICD) was added. Finally, as recently reported, acutely induced hyperkalemia led to both a marked decrease in QT<jats:sub>c<\/jats:sub> and functional improvement in repolarization (consistent 1:1 AV conduction at rates to 180 beats\/min). Spironolactone and dietary potassium were added and have produced the same effects chronically.<\/jats:p><jats:p> <jats:italic>Conclusions<\/jats:italic>: High\u2010rate atrial pacing with 2:1 AV block is presented as a novel and \u201cbridging\u201d therapy for neonatal long QT syndrome and 2:1 AV block with ventricular arrhythmias. Definitive therapy with ICD implantation was then possible when patient size was substantially increased. The electrophysiologic response to intentional elevation of the serum potassium suggests a genetic defect in an inward potassium channel and demonstrates a possible therapy of long QT syndrome in some future patients.<\/jats:p>","DOI":"10.1111\/j.1540-8167.1997.tb00840.x","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T11:42:15Z","timestamp":1180093335000},"page":"812-817","source":"Crossref","is-referenced-by-count":21,"title":["High\u2010Rate Atrial Pacing as an Innovative Bridging Therapy in a Neonate with Congenital Long QT Syndrome"],"prefix":"10.1111","volume":"8","author":[{"given":"RONN E.","family":"TANEL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN K.","family":"TRIEDMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EDWARD P.","family":"WALSH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL R.","family":"EPSTEIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANET M.","family":"De LUCCA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"JOHN E.","family":"MAYER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN B.","family":"FISHBERGBR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. PHILIP","family":"SAUL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199206000-00022"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/eurheartj\/12.7.838","article-title":"Prolonged QT, atrioventricular block, and sudden death in the newborn: An electrophysiologic evaluation","volume":"12","author":"Saoudi N","year":"1991","journal-title":"Eur Heart J"},{"key":"e_1_2_1_4_2","first-page":"16","article-title":"Prolonged QT interval and 2:1 atrioventricular block","volume":"94","author":"Battiste CE","year":"1993","journal-title":"Kans Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90222-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90634-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.10.776"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.6.1866"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90940-W"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90359-W"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.68.3.369"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80203-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.1018"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.10.2929"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000175961"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1990.tb02077.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90358-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90340-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.1.17"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.1997.tb00840.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.1997.tb00840.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T13:07:01Z","timestamp":1698412021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.1997.tb00840.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["10.1111\/j.1540-8167.1997.tb00840.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.1997.tb00840.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}