{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:19:36Z","timestamp":1771625976817,"version":"3.50.1"},"reference-count":185,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":2697,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>LQTS as a Paradigm. The inherited long QT syndrome (LQTS) is a familial disease characterized by QT interval changes that often are labile, syncope, and sudden death due to arrhythmias, predominantly in young people. Multiple mutations in five genes encoding structural subunits of cardiac ion channels now have been identified in families with LQTS. Correlations are being described between genotype and specific clinical features in LQTS. However, increasing screening of affected families and sporadic cases has identified incomplete penetrance with highly variable clinical manifestations, even among individuals carrying the same mutations. The identification of LQTS disease genes represents a crucial first step in developing an understanding of the molecular basis for normal cardiac repolarization. This information will be important not only for identifying new therapies in LQTS, but also in further understanding arrhythmias, and their potential therapies, in situations such as heart failure, cardiac hypertrophy, myocardial infarction, or sudden infant death syndrome, where abnormal repolarization has been linked to sudden death. LQTS thus presents a new paradigm to cardiac electrophysiology, in which new molecular information is being brought to bear both on clinical management of patients and on development of a new framework to study the fundamental causes of arrhythmias and new approaches to therapy.<\/jats:p>","DOI":"10.1111\/j.1540-8167.1999.tb00231.x","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T13:32:50Z","timestamp":1177075970000},"page":"1664-1683","source":"Crossref","is-referenced-by-count":104,"title":["Inherited Long QT Syndromes:"],"prefix":"10.1111","volume":"10","author":[{"given":"DAN M.","family":"RODEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER M.","family":"SPOONER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806113382401"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.8.1996"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6363(96)00122-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1997.tb03627.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.4065\/73.3.250"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899808999385"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199601000-00001"},{"key":"e_1_2_1_9_2","first-page":"788","volume-title":"Cardiac Electrophysiology: From Cell to Bedside","author":"Schwartz PJ","year":"1999"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1673802"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-17"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3194754"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1197-338"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/384078a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/384080a0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.8.3438"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90358-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90340-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.2.554"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90359-3"},{"key":"e_1_2_1_21_2","first-page":"1114","article-title":"Mapping of a gene for long QT syndrome to chromosome 4q25\u201327","volume":"57","author":"Schott JJ","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80728-X"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.17.5472"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.2208"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.27.16713"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/35416"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5360.69"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/350232a0"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.33.21061"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.42.27231"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.39.24109"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.12.6837"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.5.870"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.5.719"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.13.1264"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1086\/302346"},{"key":"e_1_2_1_37_2","first-page":"1","article-title":"Expression of KvLQTl in human ventricular epicardial, midmyocardial, and endocardial layers","volume":"98","author":"Demolombe S","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0297-186"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050554"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705293362204"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80255-X"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.2.146"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.24.2420"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/376683a0"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13200"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.5.916"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.7.640"},{"key":"e_1_2_1_48_2","first-page":"1","article-title":"A mutation (E1784K) in the carboxyl terminus of the cardiac Na+ channel causes autosomal dominant congenital long QT syndrome","volume":"98","author":"Wang DW","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00033-7"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.6.H2016"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.2.141"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.5.457"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.8.2595"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/32675"},{"key":"e_1_2_1_55_2","first-page":"1","article-title":"Human SCN5A gene mutations alter Na\u2010current kinetics and associate with VF in patients without structural heart disease","volume":"98","author":"Rook MB","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_56_2","first-page":"1","article-title":"Molecular heterogeneity in the Brugada syndrome","volume":"98","author":"McNamara DM","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.2.277"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703273361302"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703133361107"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5364.750"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00332-X"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.20.2049"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1998)11:2<158::AID-HUMU9>3.0.CO;2-F"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209173271204"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00454-8"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.4.529"},{"key":"e_1_2_1_67_2","first-page":"1","article-title":"The loss of function induced by HERG and KVLQT1 mutations does not correlate with the clinical severity of the long QT syndrome","volume":"98","author":"Priori SG","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00262.x"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391404"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.22.2237"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.2778"},{"key":"e_1_2_1_72_2","first-page":"1","article-title":"Identification of a long QT syndrome molecular defect in drug\u2010induced torsades de pointes","volume":"96","author":"Napolitano C","year":"1997","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_73_2","first-page":"1","article-title":"Do mutations in cardiac ion channel genes predispose to drug\u2010induced (acquired) long QT syndrome","volume":"96","author":"Schulze\u2010Bahr E","year":"1997","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb00148.x"},{"key":"e_1_2_1_75_2","first-page":"1","article-title":"The differentiating features of the Romano\u2010Ward and the Jervell and Lange\u2010Nielsen syndromes","volume":"96","author":"Hajj\u2010Ali R","year":"1997","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.10.2929"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0151"},{"key":"e_1_2_1_78_2","first-page":"1","article-title":"Morphological abnormalities of the T wave on Holter recordings have a diagnostic but not a prognostic value","author":"Guicheney P","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.3006"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(98)80074-5"},{"key":"e_1_2_1_81_2","first-page":"1","article-title":"Gene\u2010specific influence on the triggers for cardiac arrest in the long QT syndrome","volume":"96","author":"Schwartz PJ","year":"1997","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.12.3381"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.3.1136"},{"key":"e_1_2_1_84_2","first-page":"1","article-title":"The risk of sudden death as first cardiac event in asymptomatic patients with the long QT syndrome","volume":"98","author":"Priori SG","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00578-6"},{"key":"e_1_2_1_86_2","first-page":"690","article-title":"Sex differences in the evolution of the electrocardiographic QT interval with age","volume":"8","author":"Rautaharju PM","year":"1992","journal-title":"Can J Cardiol"},{"key":"e_1_2_1_87_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510210076031"},{"key":"e_1_2_1_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.6.1471"},{"key":"e_1_2_1_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/40805"},{"key":"e_1_2_1_90_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.19.11745"},{"key":"e_1_2_1_91_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.41.25824"},{"key":"e_1_2_1_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6309"},{"key":"e_1_2_1_93_2","first-page":"1","article-title":"Coexpression of a beta subunit enhances the effect of a phorbol ester on the Kvl.5 channel","volume":"94","author":"Murray KT","year":"1996","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_94_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117838"},{"key":"e_1_2_1_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0297-181"},{"key":"e_1_2_1_96_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-24-09423.1997"},{"key":"e_1_2_1_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80216-1"},{"key":"e_1_2_1_98_2","first-page":"1","article-title":"Asthma in the long QT syndrome: A modifier of cardiac morbidity","volume":"96","author":"Rosero SZ","year":"1997","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_99_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119335"},{"key":"e_1_2_1_100_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.1.103"},{"key":"e_1_2_1_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.1997.tb00336.x"},{"key":"e_1_2_1_102_2","first-page":"1218","article-title":"Frequency\u2010dependent interactions of mexiletine and quinidine on depolarization and repolarization in canine Purkinje fibers","volume":"243","author":"Roden DM","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00234-U"},{"key":"e_1_2_1_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1997.tb01019.x"},{"key":"e_1_2_1_105_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.2038"},{"key":"e_1_2_1_106_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.54.1.220"},{"key":"e_1_2_1_107_2","first-page":"844","article-title":"Quinidine enhances and suppresses Kv1.2 from outside and inside the cell, respectively","volume":"279","author":"Tseng GN","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_108_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.16.1581"},{"key":"e_1_2_1_109_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1995.tb00400.x"},{"key":"e_1_2_1_110_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.36.477"},{"key":"e_1_2_1_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80124-5"},{"key":"e_1_2_1_112_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.60.1.667"},{"key":"e_1_2_1_113_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374988"},{"key":"e_1_2_1_114_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.3.407"},{"key":"e_1_2_1_115_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.6.782"},{"key":"e_1_2_1_116_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.1018"},{"key":"e_1_2_1_117_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2149"},{"key":"e_1_2_1_118_2","first-page":"1","article-title":"Long\u2010term follow\u2010up of patients with the idiopathic long\u2010QT syndrome treated with combined beta\u2010blockers and chronic pacing","volume":"96","author":"Dorostkar PC","year":"1997","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(75)90089-7"},{"key":"e_1_2_1_120_2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0022-3565(24)37893-0","article-title":"KN\u201093. an inhibitor of multifunctional Ca2+\/calmodulin dependent protein kinase, decreases early after depolarizations in rabbit heart","volume":"287","author":"Anderson ME","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_121_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5361"},{"key":"e_1_2_1_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050717"},{"key":"e_1_2_1_123_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0236"},{"key":"e_1_2_1_124_2","first-page":"851","article-title":"In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N\u2010acetyl procainamide","volume":"217","author":"Dangman KH","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_125_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.4.846"},{"key":"e_1_2_1_126_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.6.857"},{"key":"e_1_2_1_127_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.3.474"},{"key":"e_1_2_1_128_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.12.4392"},{"key":"e_1_2_1_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00588-8"},{"key":"e_1_2_1_130_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.5.1376"},{"key":"e_1_2_1_131_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.63.6.342"},{"key":"e_1_2_1_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00333-1"},{"key":"e_1_2_1_133_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-7-549"},{"key":"e_1_2_1_134_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1997.tb01018.x"},{"key":"e_1_2_1_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)91309-4"},{"key":"e_1_2_1_136_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.5.1557"},{"key":"e_1_2_1_137_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.64.5.977"},{"key":"e_1_2_1_138_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586939"},{"key":"e_1_2_1_139_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.70.3.445"},{"key":"e_1_2_1_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00313-4"},{"key":"e_1_2_1_141_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1994.tb01133.x"},{"key":"e_1_2_1_142_2","first-page":"1135","article-title":"A selective blocker for rested T\u2010type Ca++ channels in guinea pig atrial cells","volume":"268","author":"Xu X","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_143_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007706022381"},{"key":"e_1_2_1_144_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.76.5.790"},{"key":"e_1_2_1_145_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.8.906"},{"key":"e_1_2_1_146_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.6.H2168"},{"key":"e_1_2_1_147_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.8.906"},{"key":"e_1_2_1_148_2","first-page":"1","article-title":"Torsade de pointes is prevented by systemic administration of a calmodulin antagonist","volume":"98","author":"Mazur A","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_149_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.72.1.75"},{"key":"e_1_2_1_150_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.68.1.77"},{"key":"e_1_2_1_151_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.2.686"},{"key":"e_1_2_1_152_2","first-page":"228","volume-title":"Cardiac Electrophysiology: From Celt to Bedside","author":"Antzelevitch C","year":"1995"},{"key":"e_1_2_1_153_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/01.RES.76.3.351","article-title":"Characteristics of the delayed rectifier current (Ikr and Iks) in canine ventricular epicardial, midmyocardial, and endocardial myocytes: A weaker Iks contributes to the longer action potential of the M cell","volume":"76","author":"Liu DW","year":"1995","journal-title":"Circ Res"},{"key":"e_1_2_1_154_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.6.1083"},{"key":"e_1_2_1_155_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.108.5.405"},{"key":"e_1_2_1_156_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.3.2001794"},{"key":"e_1_2_1_157_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118032"},{"key":"e_1_2_1_158_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3083"},{"key":"e_1_2_1_159_2","first-page":"79","article-title":"Redistribution of the Kvl.5 potassium channel protein on the surface of myocytes from the epicardial border zone of the infracted canine heart","volume":"2","author":"Mays DJ","year":"1997","journal-title":"Cardiovasc Pathobiol"},{"key":"e_1_2_1_160_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.1.95"},{"key":"e_1_2_1_161_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26505"},{"key":"e_1_2_1_162_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.5.560"},{"key":"e_1_2_1_163_2","first-page":"1","article-title":"Expression of a dominant negative Kv4.2 channel in the hearts of transgenic mice","volume":"96","author":"Wickenden AD","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_164_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.6.668"},{"key":"e_1_2_1_165_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.7.933"},{"key":"e_1_2_1_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00274-5"},{"key":"e_1_2_1_167_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.2.379"},{"key":"e_1_2_1_168_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.2.262"},{"key":"e_1_2_1_169_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.14.1383"},{"key":"e_1_2_1_170_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.5.2534"},{"key":"e_1_2_1_171_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.969"},{"key":"e_1_2_1_172_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.4.777"},{"key":"e_1_2_1_173_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.23.2545"},{"key":"e_1_2_1_174_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.75.3.443"},{"key":"e_1_2_1_175_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.3.1175"},{"key":"e_1_2_1_176_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.3.436"},{"key":"e_1_2_1_177_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.4.988"},{"key":"e_1_2_1_178_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0900447"},{"key":"e_1_2_1_179_2","first-page":"1","article-title":"Reduced electrical coupling between ventricular cell pairs from the epicardial border zone of canine myocardial infarcts","volume":"98","author":"Yao JA","year":"1998","journal-title":"(Abstract) Circulation"},{"key":"e_1_2_1_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00013-9"},{"key":"e_1_2_1_181_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1998.tb00915.x"},{"key":"e_1_2_1_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90210-8"},{"key":"e_1_2_1_183_2","first-page":"H1386","article-title":"Ca(2+)\u2010dependent outward currents in myocytes from epicardial border zone of 5\u2010day infarcted canine heart","volume":"273","author":"Aggarwal R","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_1_184_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.92.4.531"},{"key":"e_1_2_1_185_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.68.2.424"},{"key":"e_1_2_1_186_2","doi-asserted-by":"publisher","DOI":"10.1038\/31960"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.1999.tb00231.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.1999.tb00231.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T21:14:08Z","timestamp":1736975648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.1999.tb00231.x"}},"subtitle":["A Paradigm for Understanding Arrhythmogenesis"],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":185,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["10.1111\/j.1540-8167.1999.tb00231.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.1999.tb00231.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}