{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:26:04Z","timestamp":1778678764589,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":2880,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p>Natriuretic Peptide System in AF. <jats:italic>Introduction<\/jats:italic>: Circulating cardiac natriuretic peptides play an important role in maintaining volume homeostasis, especially during conditions affecting hemodynamics. During atrial fibrillation (AF), levels of plasma atrial natriuretic peptide (ANP) becomes elevated. The aim of this study was to gather information about gene expression of the natriuretic peptide system on the atrial level in patients with AF.<\/jats:p><jats:p> <jats:italic>Methods and Results<\/jats:italic>: Right atrial appendages of 36 patients with either paroxysmal or persistent AF were compared with 36 case matched controls in sinus rhythm for mRNA expression of pro\u2010 atrial natriuretic peptide (pro\u2010ANP), pro\u2010brain natriuretic peptide (pro\u2010BNP), and their natriuretic peptide receptor type\u2010A (NPR\u2010A). We investigated patients without (n = 36) and with (n = 36) valvular disease. Persistent AF was associated with higher mRNA expression of pro\u2010BNP (+66%, P = 0.04, in patients without valvular disease, and +69%, P &lt; 0.01, in patients with valvular disease) and lower mRNA expression of NPR\u2010A (\u201058%, P = 0.02, in patients witbout valvular disease, and \u201062%, P &lt; 0.01, in patients with valvular disease). The mRNA content of pro\u2010ANP was only increased in patients with valvular disease (+12%, P = 0.03). No changes were observed in patients with paroxysmal AF.<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: This study demonstrates that persistent, but not paroxysmal, AF induces alterations in gene expression of pro\u2010BNP and NPR\u2010A on the atrial level. Although AF generally is associated with an increase of plasma ANP level, a change in mRNA content of pro\u2010ANP is only observed in the presence of concomitant valvular disease and is of minor magnitude.<\/jats:p>","DOI":"10.1111\/j.1540-8167.1999.tb00263.x","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T14:01:39Z","timestamp":1177077699000},"page":"827-835","source":"Crossref","is-referenced-by-count":48,"title":["Gene Expression of the Natriuretic Peptide System in Atrial Tissue of Patients with Paroxysmal and Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"10","author":[{"given":"ANTON E.","family":"TUINENBURG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BIANCA J.J.M.","family":"BRUNDEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ISABELLE C.","family":"Van 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