{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:41:53Z","timestamp":1789342913408,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":2453,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>QT Dispersion and Repolarization Heterogeneity. <jats:italic>Introduction<\/jats:italic>: QT dispersion (QTd, range of QT intervals in 12 ECG leads) is thought to reflect spatial heterogeneity of ventricular refractoriness. However, QTd may be largely due to projections of the repolarization dipole rather than \u201cnondipolar\u201d signals.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> Seventy\u2010eight normal subjects (47 \u00b1 16 years, 23 women), 68 hypertrophic cardiomyopathy patients (HCM; 38 \u00b1 15 years. 21 women), 72 dilated cardiomyopathy patients (DCM; 48 \u00b1 15 years, 29 women), and 81 survivors of acute myocardial infarction (AMI; 63 \u00b1 12 years, 20 women) had digital 12\u2010lead resting supine ECGs recorded (10 ECGs recorded in each subject and results averaged). In each ECG lead, QT interval was measured under operator review by QT Guard (GE Marquette) to obtain QTd. QTd was expressed as the range, standard deviation, and highest\u2010to\u2010lowest quartile difference of QT interval in all measurable leads. Singular value decomposition transferred ECGs into a minimum dimensional time orthogonal space. The first three components represented the ECG dipole; other components represented nondipolar signals. The power of the T wave nondipolar within the total components was computed to measure spatial repolarization heterogeneity (relative T wave residuum, TWR). OTd was 33.6 \u00b1 18.3, 47.0 \u00b1 19.3, 34.8 \u00b1 21.2, and 57.5 \u00b1 25.3 msec in normals, HCM, CM, and AMI, respectively (normals vs DCM: NS, other P &lt; 0.009). TWR was 0.029%\u00b1 0.031%, 0.067%\u00b1 0.067%, 0.112%\u00b1 0.154%, and 0.186%\u00b1 0.308% in normals, HCM, DCM, and AMI (HCM vs DCM: NS. other P &lt; 0.006), The correlations between QTd and TWR were r = \u20100.0446, 0.2805, \u20100.1531, and 0.0771 (P = 0.03 for HCM, other NS) in normals, HCM, DCM, and AMI, respectively.<\/jats:p><jats:p> <jats:italic>Conclusion<\/jats:italic>: Spatial heterogeneity of ventricular repolarization exists and is measurable in 12\u2010lead resting ECGs. It differs between different clinical groups, but the so\u2010called QT dispersion is unrelated to it.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2000.tb00061.x","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T13:10:42Z","timestamp":1177074642000},"page":"835-843","source":"Crossref","is-referenced-by-count":128,"title":["QT Dispersion Does Not Represent Electrocardiographic Interlead Heterogeneity of Ventricular Repolarization"],"prefix":"10.1111","volume":"11","author":[{"given":"MAREK","family":"MALIK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BURAK","family":"ACAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YI","family":"GANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YEE GUAN","family":"YAP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATERINA","family":"HNATKOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. JOHN","family":"CAMM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.63.6.342"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1996.tb00583.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.4.390"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.20.2160"},{"key":"e_1_2_1_6_2","first-page":"887","article-title":"Amiodarontherapie nach Sotalol\u2010induzierter Torsade dc pointes: QT\u2010Verlangerung und QT Dispersion zur Differenzirung proarrhythmischer Effekte","volume":"83","author":"Loo A","year":"1994","journal-title":"Z Kardiol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1995.tb00368.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.5.467"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1094"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90697-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.4.1681"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.25.2543"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00696-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00446-W"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1998.tb00103.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(98)90305-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.11.1458"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.841"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(98)80072-1"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00927-2"},{"key":"e_1_2_1_21_2","first-page":"69","article-title":"Comparison of three measures of QT dispersion","volume":"26","author":"Langley P","year":"1999","journal-title":"Comput Cardiol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.748984"},{"key":"e_1_2_1_23_2","first-page":"70","volume-title":"Matrix Computation","author":"Golub GH","year":"1996"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02513351"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10190-8"},{"key":"e_1_2_1_26_2","article-title":"Analysis of twelve\u2010lead T wave morphology for risk stratification after myocardial infarction","author":"Zabel M","journal-title":"Circulation"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.80.5.459"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90410-3"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2000.tb00061.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2000.tb00061.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T17:13:15Z","timestamp":1698599595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2000.tb00061.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1111\/j.1540-8167.2000.tb00061.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2000.tb00061.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}