{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:45:30Z","timestamp":1770065130552,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,4,12]],"date-time":"2005-04-12T00:00:00Z","timestamp":1113264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> Cardiac resynchronization therapy (CRT) has been introduced to treat patients with end\u2010stage heart failure, and results of this technique are promising. The aim of our study was to assess the sustained benefit of CRT in a large patient cohort with end\u2010stage heart failure at long\u2010term follow\u2010up. In addition, the prognosis of responders and nonresponders was evaluated.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> 125 patients with end\u2010stage heart failure, NYHA class III or IV, LVEF &lt;35%, QRS duration &gt;120 msec and left bundle branch block morphology received a biventricular device. At baseline and 6 months after implantation the following parameters were evaluated: NYHA class, Minnesota Quality of life score, QRS duration on surface ECG, 6\u2010minute walking distance and LVEF. Follow\u2010up was obtained up to 3 years. After 6 months, patients were divided in clinical responders and nonresponders according to improvement in NYHA class. All clinical parameters improved significantly at 6\u2010month follow\u2010up. Hospitalization for heart failure was 3.8 \u00b1 4.9 days\/year before and 0.7 \u00b1 1.6 days\/year after CRT. Survival at 1\u2010, 2\u2010, and 3\u2010year follow\u2010up was 93%, 88%, and 85%, respectively. Responders (78%) showed a significantly better survival than nonresponders at 2\u2010 and 3\u2010year follow\u2010up (96% and 93% for responders versus 81% and 73% for nonresponders, P &lt; 0.05).<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> The improvement in functional status and symptoms after CRT is maintained at long\u2010term follow\u2010up (up to 3 years). The clinical improvement was associated with a significant reduction in hospitalization rate which was also maintained over the years. Preimplantation selection of responders may result in even better long\u2010term survival.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2005.40685.x","type":"journal-article","created":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T14:16:25Z","timestamp":1120745785000},"page":"701-707","source":"Crossref","is-referenced-by-count":37,"title":["Long\u2010Term Follow\u2010Up of Cardiac Resynchronization Therapy in Patients with End\u2010Stage Heart Failure"],"prefix":"10.1111","volume":"16","author":[{"given":"SANDER G.","family":"MOLHOEK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEROEN J.","family":"BAX","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GABE B.","family":"BLEEKER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EDUARD 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