{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:09:34Z","timestamp":1791083374278,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T00:00:00Z","timestamp":1139875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> The ligament of Marshall (LOM) or the oblique vein of Marshall (VOM) in the left atrium (LA) is one of the origins of nonpulmonary vein ectopies causing atrial fibrillation. The distributions of myocardial bundles (Marshall bundles; MBs) and autonomic nerves adjacent to the LOM have not been completely elucidated.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> Twenty\u2010eight human hearts were examined postmortem. The inferolateral LA myocardium was dissected en block and cut perpendicularly to the atrioventricular ring. The specimens were sectioned at 1\u2010mm intervals and stained with hematoxylin and eosin, and Azan\u2010Mallory. In addition, S\u2010100 and tyrosine hydroxylase (TH) were employed for the immunohistochemical analysis of the sympathetic and parasympathetic fibers. In 25 cases, MBs were observed. Although the MBs surrounded the VOM at the coronary sinus (CS) juncture, they gradually diminished in density toward the distal venous branch. The connections of the MBs and LA myocardium were frequently observed in the CS juncture and anterior wall of the left pulmonary vein (PV)\u2010LA junctions. TH\u2010stained sympathetic nerve fibers were densely distributed around the PV\u2010LA junctions. On the other hand, non\u2010TH\u2010stained parasympathetic ganglions were mainly observed at the CS juncture.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> MB\u2010LA connections were mainly observed at the CS juncture and PV\u2010LA junctions. The association between sympathetic nerve fibers and MBs was distinct at the PV\u2010LA junctions. At the CS juncture, the regression of the sympathetic nerve fibers and the increase of parasympathetic ganglions were observed. The diverse arrangement and autonomic innervation of MBs seem to characterize the LOM region in humans.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2006.00375.x","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T09:41:09Z","timestamp":1139910069000},"page":"594-599","source":"Crossref","is-referenced-by-count":110,"title":["Diverse Myocardial Extension and Autonomic Innervation on Ligament of Marshall in Humans"],"prefix":"10.1111","volume":"17","author":[{"given":"MUTSUKI","family":"MAKINO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHIN","family":"INOUE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKA\u2010AKI","family":"MATSUYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GENYOU","family":"OGAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TETSUO","family":"SAKAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOU\u2010ICHI","family":"KOBAYASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKASHI","family":"KATAGIRI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDEKAZU","family":"OTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,14]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391003"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.20.2463"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104712"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095796.45180.88"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000074206.52056.2D"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.13.1503"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00750.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.8.1157"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00819-6"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-9602(03)80122-X"},{"key":"e_1_2_8_12_2","first-page":"10.7","volume-title":"Cardiac Anatomy: An Integrated Text and Colour Atlas","author":"Anderson RH","year":"1980"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.88.1.4"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1054\/jelc.2003.50004"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116753.56467.BC"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.58.389"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2003.12.001"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb01167.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10269"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20006"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00679.x"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199702)247:2<289::AID-AR15>3.0.CO;2-L"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.50048.x"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03651.x"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2006.00375.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2006.00375.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:08:19Z","timestamp":1696968499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2006.00375.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,14]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1540-8167.2006.00375.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2006.00375.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,14]]}}}