{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:20:27Z","timestamp":1697433627481},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,28]],"date-time":"2006-02-28T00:00:00Z","timestamp":1141084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> Implantable atrial defibrillators (IADs) have proved to be safe and effective in the management of atrial fibrillation. A potential limitation of self\u2010activated IAD therapy is patient\u2010reported pain and anxiety. The main objective of the present study was to determine whether triazolam improved patient perception of the shock experience or altered patient memory of shock discomfort relative to placebo.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> A total of 15 men and women (mean age: 59 \u00b1 6 years) were enrolled in this double\u2010blind, placebo\u2010controlled, crossover study of triazolam. Randomized study medication was administered orally 75 minutes prior to scheduled atrial shock delivery. Patient perception of the shock experience was assessed along with sedation, memory, anxiety, and mood. Triazolam reduced mean pre\u2010shock anxiety (<jats:italic>t<\/jats:italic>= 2.98, df = 14, P = 0.01) and shock\u2010related pain (<jats:italic>t<\/jats:italic>= 2.74, df = 13, P = 0.01) and intensity (<jats:italic>t<\/jats:italic>= 2.64, df = 13, P = 0.018) relative to placebo. Similarly, participants recalled less discomfort the morning after shock with triazolam than with placebo (<jats:italic>t<\/jats:italic>= 2.82, df = 11, P = 0.017).<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> This study was the first to investigate the use of an oral benzodiazepine administered prior to patient\u2010activated shock delivery with an IAD. Our data indicate that oral triazolam is beneficial in decreasing pain and anxiety associated with self\u2010activated atrial defibrillation. If triazolam provides a similar benefit in the community to that which has been reported here, this medication could be offered to patients as an adjunct to intermittent IAD therapy.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2006.00416.x","type":"journal-article","created":{"date-parts":[[2006,2,28]],"date-time":"2006-02-28T08:27:18Z","timestamp":1141115238000},"page":"391-395","source":"Crossref","is-referenced-by-count":6,"title":["Decreasing Pain and Anxiety Associated with Patient\u2010Activated Atrial Shock: A Placebo\u2010Controlled Study of Adjunctive Sedation with Oral Triazolam"],"prefix":"10.1111","volume":"17","author":[{"given":"TANYA J.","family":"FABIAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID S.","family":"SCHWARTZMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL R.","family":"UJHELYI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHARON E.","family":"COREY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTIN L.","family":"BIGOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUCE G.","family":"POLLOCK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICIA D.","family":"KROBOTH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.03108.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2004.00468.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2004.03406.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF00280132","article-title":"The pharmacokinetics and pharmacodynamics of sublingual and oral alprazolam in the post\u2010prandial state","volume":"42","author":"Scavone JM","year":"1992","journal-title":"Eur J Clin Pharmacol"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02243999"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200002000-00005"},{"key":"e_1_2_7_8_2","first-page":"970\u20101\u2010970\u201028","volume-title":"Administration Manual\u2014Randt Memory Test","author":"Randt CT","year":"1983"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4943(85)90042-1"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199502000-00002"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245415"},{"key":"e_1_2_7_12_2","volume-title":"Stat\u2010Trait Anxiety Inventory","author":"Spielberger CD","year":"1970"},{"key":"e_1_2_7_13_2","volume-title":"Manual for the Profile of Mood States","author":"McNair DM","year":"1971"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199508000-00004"},{"key":"e_1_2_7_15_2","volume-title":"Analyzing Data with GraphPad Prism","author":"Motulsky HJ","year":"1999"},{"key":"e_1_2_7_16_2","volume-title":"SAS\/STAT Users Guide","author":"SAS InstituteI","year":"2000"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90055-X"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1987.tb05599.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(97)00086-9"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2006.00416.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2006.00416.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T12:03:51Z","timestamp":1697371431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2006.00416.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,28]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1540-8167.2006.00416.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2006.00416.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,28]]}}}