{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T14:50:41Z","timestamp":1715957441686},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> Atrial fibrillation impacts the clinical course of up to 50% of patients with advanced heart failure (HF) who are eligible for cardiac resynchronization therapy with a defibrillator (CRT\u2010D). While RV\u2010based defibrillators are available with advanced atrial diagnostics and therapies that provide rapid diagnosis and treatment of spontaneously occurring atrial tachycardia\/fibrillation (AT\/AF) episodes, there is no CRT\u2010D device that combines atrial\/ventricular and CRT therapies.<\/jats:p><jats:p> <jats:italic>Purpose:<\/jats:italic> The purpose of the prospective multicenter RENEWAL<jats:sup>\u00ae<\/jats:sup> 3 AVT study is to assess the performance of atrial diagnostics and therapies used in combination with a CRT\u2010D device.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> Enrolled patients were required to have indications for a CRT\u2010D device and a documented episode of AT\/AF within 12 months of enrollment. A total of 170 patients were enrolled over 9 months (85% male; mean age 72 \u00b1 10 years; NYHA classification: 88% III, 12% IV; left ventricular ejection fraction [LVEF] mean 23 \u00b1 6%; mean QRS duration 150 \u00b1 25 msec; 78% ischemic etiology). The documented atrial arrhythmia was AF in 77% of patients. A total of 60% of patients had the CRT\u2010D device placed for primary prevention of sudden death and 40% of patients had a history of ventricular arrhythmia in addition to HF. The device operates in the biventricular (BiV) triggered mode for sensed ventricular events associated with AF.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> A total of 159 patients (95%) had a successful CRT\u2010D implant. Over a mean follow\u2010up of 5.7 \u00b1 2.3 months, there were a total of 152 atrial shocks delivered in 108 patients for induced (93%) or spontaneous (7%) occurring episodes of AF. Spontaneously occurring AF was observed in 40 patients (25%). The rate of first shock conversion was 118\/152 (78%, mean energy 11.6 \u00b1 5.9 J). Overall shock therapy conversion rate was 138\/152 (91%). The number of shock conversions resulting in sinus rhythm maintained for at least 2 minutes postshock was 87% for induced episodes. Therapy was delivered for spontaneous ventricular tachycardia\/fibrillation in nine patients (6%). There was no instance of ventricular proarrhythmia associated with atrial shock therapies, undersensing of ventricular arrhythmias, or interruption of CRT therapy associated with the combined device.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> In CRT\u2010D candidates with a history of AF, 25% experience recurrent AF within 6 months of implant. Atrial detection and ventricular detection, shock, and resynchronization therapies are not compromised by the addition of atrial therapies to a CRT\u2010D device.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2006.00440.x","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T10:05:50Z","timestamp":1141207550000},"page":"520-525","source":"Crossref","is-referenced-by-count":10,"title":["Results of the Multicenter RENEWAL<sup>\u00ae<\/sup> 3 AVT Clinical Study of Cardiac Resynchronization Defibrillator Therapy in Patients with Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"17","author":[{"given":"LESLIE A.","family":"SAXON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RUTH ANN","family":"GREENFIELD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRIAN G.","family":"CRANDALL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHARLES C.","family":"NYDEGGER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL","family":"ORLOV","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RHONDA","family":"VAN GENDEREN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"716","article-title":"Hospitalization for arrhythmias in the United States: Importance of atrial fibrillation","volume":"19","author":"Baily D","year":"1992","journal-title":"Am J Cardiol"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90454-9"},{"key":"e_1_2_7_4_2","volume-title":"2002 Heart and Stroke Statistical Update","author":"American Heart Association","year":"2002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.5.628"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1767"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(02)00129-1"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_7_10_2","unstructured":"http:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfPMA\/pma.cfm. FDA\/Center for Devices and Radiological Health searchable website for all CRT & ICD device labels. Accessed June 13 2005."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:JICE.0000011490.32755.40"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023652732297"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CEPR.0000023136.45408.24"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.2039"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/oxfordjournals.eurheartj.a061437","article-title":"Efficacy of i.v. amiodarone in converting rapid atrial fibrillation and flutter to sinus rhythm in intensive care patients","volume":"4","author":"Faniel R","year":"1983","journal-title":"Eur Heart J"},{"key":"e_1_2_7_16_2","first-page":"6","article-title":"Cardiac resynchronization therapy: Will ancillary atrial rate support promote greater utilization of \u00df\u2010blockers in heart failure","volume":"40","author":"De Marco T","year":"2000","journal-title":"J Card Fail"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2685"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)01042-8"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2006.00440.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2006.00440.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:28:31Z","timestamp":1696966111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2006.00440.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1540-8167.2006.00440.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2006.00440.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}