{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:45:31Z","timestamp":1762505131168},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T00:00:00Z","timestamp":1146528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p> <jats:italic>Objective:<\/jats:italic> To simulate right ventricular outflow tract tachycardia (RVOT\u2010VT) in experimental animals.<\/jats:p><jats:p> <jats:italic>Background:<\/jats:italic> The mechanism(s) whereby a discrete area of myocardium in the RVOT becomes arrhythmogenic remains unknown.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> In 13 dogs, a circular catheter was placed in the proximal pulmonary artery (PA) to contact the endovascular circumference of the PA. A 50\u2010msec train of high\u2010frequency stimulation (HFS, 200 Hz), coupled to atrial pacing, was applied at each bipolar pair of the circular catheter. The coupling interval was adjusted so that the 50\u2010msec train occurred during the ventricular refractory period, that is, the QRS complex, in order to prevent stimulation of the myocardial sleeve within the proximal PA.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> In all dogs, HFS induced ventricular premature depolarizations and VTs with a left bundle branch block (LBBB) morphology and inferior axis <jats:styled-content>(average 6.8 \u00b1 1.6 V)<\/jats:styled-content>. Earliest activation was consistently recorded from the proximal PA. Esmolol, a short\u2010acting beta\u2010blocker (1 mg\/kg), was administered intravenously in 11 dogs. The inducible ventricular ectopy was abolished in 10 dogs <jats:styled-content>(&gt;12 V, P &lt; 0.05)<\/jats:styled-content> and the response to HFS was blunted in one dog (10\u201311 V). After 30 minutes, the response to HFS returned to pre\u2010esmolol levels.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> Stimulation of the sympathetic input to the proximal PA induces ventricular ectopy and VTs exhibiting a left bundle branch block morphology and inferior axis, closely simulating clinical RVOT\u2010VT. Beta\u2010blockade either abolishes or blunts this response, corroborating the sympathetic etiology in this model and in some clinical cases of RVOT tachycardias.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2006.00509.x","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T05:58:33Z","timestamp":1146635913000},"page":"771-775","source":"Crossref","is-referenced-by-count":23,"title":["Experimental Model Simulating Right Ventricular Outflow Tract Tachycardia: A Novel Technique to Initiate RVOT\u2010VT"],"prefix":"10.1111","volume":"17","author":[{"given":"JING","family":"ZHOU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BENJAMIN J.","family":"SCHERLAG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM","family":"YAMANASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YAN","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RALPH","family":"LAZZARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WARREN M.","family":"JACKMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUNNY S.","family":"PO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00633.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B0-7216-0323-8\/50075-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021148711621"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90832-W"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90375-1"},{"key":"e_1_2_6_7_2","first-page":"17","volume-title":"Neurocardiology","author":"Ardell J","year":"1994"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199702)247:2<289::AID-AR15>3.0.CO;2-L"},{"key":"e_1_2_6_9_2","first-page":"1199","article-title":"Regional cardiac distribution of the sympathetic nerves","volume":"31","author":"Randall W","year":"1972","journal-title":"Fed Proc"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2004.00672.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1994.tb01348.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00281.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.071"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01767-3"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.49.5.848"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2006.00509.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2006.00509.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T02:30:56Z","timestamp":1697337056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2006.00509.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,2]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1540-8167.2006.00509.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2006.00509.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,2]]}}}