{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:04:57Z","timestamp":1793318697431,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T00:00:00Z","timestamp":1168387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>\n                    <jats:italic>Background:<\/jats:italic>\n                    A high\u2010intensity\u2010focused ultrasound balloon catheter (HIFU\u2010BC) is designed to isolate pulmonary veins (PV) outside the ostia (PV antrum). This catheter uses a parabolic CO\n                    <jats:sub>2<\/jats:sub>\n                    balloon (behind water balloon) to focus a 20\u2010, 25\u2010, or 30\u2010mm diameter ring of ultrasound forward of the balloon (parallel to catheter shaft). The purpose of this study is to test the safety and efficacy of the HIFU\u2010BC for PV antrum isolation in patients with atrial fibrillation (AF).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods and Results:<\/jats:italic>\n                    Twenty\u2010seven patients with paroxysmal (19 patients) or persistent (8 patients) AF were studied. Double transseptal puncture was performed for left atrial deployment of a Lasso catheter (for PV mapping) and the 14 Fr HIFU\u2010BC. The HIFU\u2010BC was positioned outside the PV orifice over a guidewire. HIFU energy (acoustic power 45 watts) was applied for 40 seconds with a 20\u2010mm sonicating ring and 40 or 60 seconds with a 25\u2010mm or 30\u2010mm sonicating ring. No other ablation system was utilized. PV antrum isolation was attempted using HIFU\u2010BC in 78 of 104 PVs (25\/27 RSPVs, all 23 LSPVs, all 23 LIPVs, all four left common trunks and 3\/27 RIPVs). HIFU\u2010BC successfully isolated 68 (87%) of the 78PV antra with 1\u201326 (median 3) HIFU applications. The complications include transient bleeding from a distal branch of the left superior PV resulting from guidewire manipulation in one patient and right phrenic nerve injury in another patient. No PV stenosis (&gt;50% narrowing) and no LA\u2010esophageal fistula occurred. At the 12\u2010month follow\u2010up, 16 (59%) of the 27 patients were free of symptomatic episodes of AF (only 3 of the 16 patients were receiving antiarrhythmic medications).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions:<\/jats:italic>\n                    Forward\u2010focused HIFU applications isolated PVs outside the PV ostium with elimination of AF in 16 (59%) of the 27 patients at 12 months following the single ablation procedure.\n                  <\/jats:p>","DOI":"10.1111\/j.1540-8167.2006.00715.x","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T04:56:39Z","timestamp":1168404999000},"page":"136-144","source":"Crossref","is-referenced-by-count":103,"title":["Initial Experience Using a Forward Directed, High\u2010Intensity Focused Ultrasound Balloon Catheter for Pulmonary Vein Antrum Isolation in Patients with Atrial Fibrillation"],"prefix":"10.1111","volume":"18","author":[{"given":"HIROSHI","family":"NAKAGAWA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MATTHIAS","family":"ANTZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOM","family":"WONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BORIS","family":"SCHMIDT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SABINE","family":"ERNST","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FEIFAN","family":"OUYANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS","family":"VOGTMANN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATSUAKI","family":"YOKOYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEBORAH","family":"LOCKWOOD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUNNY S.","family":"PO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAREN J.","family":"BECKMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. WYN","family":"DAVIES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KARL\u2010HEINZ","family":"KUCK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WARREN M.","family":"JACKMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.20.2463"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095796.45180.88"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1161\/CIRCULATIONAHA.104.491530","article-title":"Freedom from atrial tachyarrhytmias after catheter ablation of atrial fibrillation: A randomized comparison between 2 current ablation strategies","volume":"111","author":"Karch MR","year":"2005","journal-title":"Circulation"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01972-1"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146786.87037.26"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000070541.83326.15"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1161\/01.CIR.0000151289.73085.36","article-title":"Recovered pulmonary vein conduction as a dominant factor for recurrent atrial tachyarrhythmias after complete circular isolation of the pulmonary veins: Lesson from double lasso technique","volume":"111","author":"Ouyang F","year":"2005","journal-title":"Circulation"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.541052"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.t01-1-00173.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00764.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131866.44650.46"},{"key":"e_1_2_5_13_2","first-page":"954A","article-title":"Pre\u2010clinical canine testing of a novel high intensity, forward\u2010focused ultrasound balloon catheter for pulmonary vein isolation","volume":"26","author":"Nakagawa H","year":"2003","journal-title":"Pacing Clin Electrophysiol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047065.49852.8F"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.046"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.04055.x"},{"key":"e_1_2_5_17_2","first-page":"869","article-title":"Time course and quantitative analysis of aftrial fibrillation espisode number and duration after circular plus linear left atrial lesions","volume":"44","author":"Kottkamp H","year":"2004","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2006.00715.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2006.00715.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:29:25Z","timestamp":1697041765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2006.00715.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,10]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1540-8167.2006.00715.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2006.00715.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,10]]}}}