{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:46:07Z","timestamp":1790423167960,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T00:00:00Z","timestamp":1172016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>\n                    <jats:italic>Objective:<\/jats:italic>\n                    To determine the sequela of right ventricular pacing in children with congenital complete atrioventricular block.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Background:<\/jats:italic>\n                    Pacing is a well\u2010accepted therapy for patients with congenital complete atrioventricular block. The long\u2010term sequela of right ventricular pacing in this population has not been well described.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods:<\/jats:italic>\n                    We performed a cohort study on all patients with congenital complete atrioventricular block who underwent pacemaker implantation at our institution from 1972 to 2004. Patients with associated congenital heart disease or ventricular dysfunction prior to pacemaker implantation were excluded.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results:<\/jats:italic>\n                    A total of 63 patients were included in the study. The median age at pacemaker implantation was 6.5 years, with an average follow\u2010up of 9.9 years. The cumulative dysfunction free survival at 20 years was 92%. In total, four patients (6%) were noted to develop LV dysfunction an average of 15.1 years after pacemaker implantation. Of 30 patients who were paced for &gt;10 years, only three (10%) developed echocardiographic evidence of LV dysfunction. Right ventricular apex pacing and prolonged QRS duration were found to be predictive of decreased long\u2010term LV systolic function (P &lt; 0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions:<\/jats:italic>\n                    Left ventricular dysfunction in patients with congenital complete atrioventricular block is a rare finding, even in those who have been paced for more than 10 years. Right ventricular apex pacing and prolonged QRS duration may be associated with decreased ventricular function over time. At this time, with such a low incidence of cardiac dysfunction, right ventricular pacing should be considered an acceptable first\u2010line therapy in this population.\n                  <\/jats:p>","DOI":"10.1111\/j.1540-8167.2006.00741.x","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:42:51Z","timestamp":1172058171000},"page":"373-377","source":"Crossref","is-referenced-by-count":103,"title":["Ventricular Function and Long\u2010Term Pacing in Children with Congenital Complete Atrioventricular Block"],"prefix":"10.1111","volume":"18","author":[{"given":"JEFFREY J.","family":"KIM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD A.","family":"FRIEDMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BENJAMIN W.","family":"EIDEM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRYAN C.","family":"CANNON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GAURAV","family":"ARORA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. O'BRIAN","family":"SMITH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARNOLD L.","family":"FENRICH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAOMI J.","family":"KERTESZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,21]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"86","article-title":"Congenital complete heart block: An international study of the natural history","volume":"4","author":"Michaelsson M","year":"1972","journal-title":"Clin Cardiol"},{"key":"e_1_2_5_3_2","first-page":"2051","volume-title":"The Science and Practice of Pediatric Cardiology","author":"Ross BA","year":"1998"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00161-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00349.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00405-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1997.tb03636.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2002.01685.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.59.6.587"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.75.2.190"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.5.733"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01209-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01048-2"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1999.tb00631.x"},{"key":"e_1_2_5_15_2","first-page":"519","article-title":"Asynchronism and right ventricular pacing","volume":"98","author":"Thambo JB","year":"2005","journal-title":"Arch Mal Coeur Vaiss"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03481.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3430"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0072"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.2005.02034.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.074"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00593-3"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000150336.86033.8D"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0661-6"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00565.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01302-X"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2004.00545.x"},{"key":"e_1_2_5_27_2","first-page":"566","article-title":"Site specific right ventricular implant pacing to optimize paced left ventricular function in the young with and without congenital heart disease","volume":"25","author":"Karpawich PP","year":"2002","journal-title":"Pacing Clin Electrophysiol"},{"key":"e_1_2_5_28_2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1152\/ajplegacy.1925.73.2.346","article-title":"The muscular reactions of the mammalian ventricles to artificial surface stimulation","volume":"73","author":"Wiggers CJ","year":"1925","journal-title":"Am J Physiol"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2006.00741.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2006.00741.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T16:06:25Z","timestamp":1697040385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2006.00741.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,21]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1540-8167.2006.00741.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2006.00741.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,21]]}}}