{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T13:10:30Z","timestamp":1750943430202},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T00:00:00Z","timestamp":1176940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> The purpose of this study was to examine BiV pacing\u2010dependent changes in QT interval and the related potential for proarrhythmia. Biventricular (BiV) pacing has emerged as a promising therapy for patients with advanced congestive heart failure (CHF) and bundle branch block (BBB).<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> One hundred and seventy\u2010six consecutive patients (123 men and 53 women; mean age 67 \u00b1 16 years) with ischemic (n = 128) or nonischemic (n = 48) cardiomyopathy in New York Heart Association Class II (8%) or III (92%) CHF (ejection fraction 24 \u00b1 9%) underwent atrial synchronous BiV pacing. The QRS, QT, and JT intervals were measured at 30 minutes after initiation of BiV pacing, at 24 hours, and at 1 month postimplant. QT interval was defined as the time interval between the initial deflection of the QRS complex and the point at which the T wave crossed the isoelectric line. At baseline, the average QRS duration was 178 \u00b1 10 ms, attributable to left BBB (n = 158) or intraventricular conduction delay (n = 18). BiV pacing resulted in a small but statistically significant reduction in QRS duration (148 \u00b1 9 ms during BiV pacing vs 178 \u00b1 10 ms at baseline [P &lt; 0.0001]), yet the QT increased to 470 \u00b1 34 ms with BiV pacing versus 445 \u00b1 32 ms at baseline [P &lt; 0.0001]). The JTc interval during BiV pacing was significantly shorter than during LV pacing (290 \u00b1 9 ms vs 320 \u00b1 20 ms, P &lt; 0.0001). During a mean follow\u2010up of 24 \u00b1 6 months, one patient developed recurrent torsade de pointes. That was eliminated once left ventricular pacing was discontinued.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> Biventricular pacing prolongs QT interval. However, the occurrence of torsade de pointes is uncommon.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2007.00818.x","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T22:04:09Z","timestamp":1178229849000},"page":"623-627","source":"Crossref","is-referenced-by-count":8,"title":["Biventricular Pacing and QT Interval Prolongation"],"prefix":"10.1111","volume":"18","author":[{"given":"ATUL","family":"BHATIA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIKRAM","family":"NANGIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOAQUIN","family":"SOLIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANWER","family":"DHALA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JASBIR","family":"SRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASOOD","family":"AKHTAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.121264"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(95)02502-2"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.12.2660"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(99)00077-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.12.1567"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441202"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01895-8"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048126.07819.37"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01122.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00310.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.18.1928"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00287.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/01.CIR.0000085066.05180.40","article-title":"Cisapride\u2010induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation","author":"Di Diego JM","year":"2003","journal-title":"Circulation"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2005.40496.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.5.H1968"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.40764.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01229-7"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2007.00818.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2007.00818.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T02:29:52Z","timestamp":1697077792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2007.00818.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,19]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1111\/j.1540-8167.2007.00818.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2007.00818.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,19]]}}}