{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:30:13Z","timestamp":1793143813580,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T00:00:00Z","timestamp":1182729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> Atrial fibrillation and atrial flutter often coexist. The long\u2010term occurrence of atrial fibrillation in patients presenting with atrial flutter alone is unknown. We report the long\u2010term follow\u2010up in patients who underwent cavotricuspid isthmus ablation for treatment of lone atrial flutter.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> Between January 1997 and June 2002, 632 patients underwent cavotricuspid isthmus ablation for the treatment of typical atrial flutter at the Cleveland Clinic Foundation. Three hundred sixty\u2010three patients were included in this study and followed for a mean duration of 39 \u00b1 11 months. The mean duration of atrial flutter symptoms was 12 \u00b1 5 months. Mean left\u2010atrial size and left\u2010ventricular ejection fraction were 4.2 \u00b1 0.8 cm and 47 \u00b1 13%, respectively. After a mean follow\u2010up time of 39 \u00b1 11 months, 13% (48 of 363) of the patients remained in sinus rhythm. Five percent (18 of 363) of patients experienced recurrence of atrial flutter only. Sixty\u2010eight percent (246 of 363) experienced the onset of atrial fibrillation and 14% (51 of 363) experienced recurrence of atrial flutter and the new onset of atrial fibrillation. Overall, 82% (297 of 363) of the patients experienced new onset of drug refractory atrial fibrillation. Left\u2010atrial size was a predictor of atrial fibrillation recurrence post\u2010atrial flutter ablation.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> At long\u2010term follow\u2010up, approximately 82% of patients post\u2010cavotricuspid isthmus ablation for atrial flutter developed drug refractory atrial fibrillation. This finding suggests that elimination of atrial flutter might delay, but does not prevent, atrial fibrillation. Evidence suggests both arrhythmias may share common triggers and such patients may derive a better long\u2010term benefit from anatomical ablative treatment of atrial fibrillation as well.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2007.00885.x","type":"journal-article","created":{"date-parts":[[2007,6,26]],"date-time":"2007-06-26T04:30:32Z","timestamp":1182832232000},"page":"799-802","source":"Crossref","is-referenced-by-count":118,"title":["Incidence of Atrial Fibrillation Post\u2010Cavotricuspid Isthmus Ablation in Patients with Typical Atrial Flutter: Left\u2010Atrial Size as an Independent Predictor of Atrial Fibrillation 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