{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:27:38Z","timestamp":1769387258210,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T00:00:00Z","timestamp":1215475200000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> Patients with heart block have conventionally received a pacemaker that stimulates the right ventricular apex (RVA) to restore heart rate control. While RVA pacing has been shown to create systolic dyssynchrony acutely, dyssynchrony can also occur in diastole. The effects of acute RVA pacing on diastolic synchrony have <jats:italic>not<\/jats:italic> been investigated. RVA pacing acutely impairs diastolic <jats:italic>function<\/jats:italic> by increasing the time constant of relaxation, decreasing the peak lengthening rate and decreasing peak negative dP\/dt. We therefore <jats:italic>hypothesized<\/jats:italic> that acute RVA pacing would cause diastolic dyssynchrony in addition to creating systolic dyssynchrony.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> Fourteen patients (13 \u00b1 4 years old) with non\u2010preexcited supraventricular tachycardia underwent ablation therapy with subsequent testing to confirm elimination of the tachycardia substrate. Normal cardiac structure and function were then documented on two\u2010dimensional echocardiography and 12\u2010lead electrocardiography prior to enrollment. Tissue Doppler images were collected during normal sinus rhythm (NSR), right atrial appendage pacing (AAI), and VVI\u2010RVA pacing during the postablation waiting interval. Systolic and diastolic dyssynchrony were quantified using cross\u2010correlation analysis of tissue Doppler velocity curves. Systolic dyssynchrony increased 81% during RVA pacing relative to AAI and NSR (P &lt; 0.01). Diastolic synchrony was <jats:italic>not<\/jats:italic> affected by the different pacing modes (P = 0.375).<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> Acute dyssynchronous activation of the LV created by RVA pacing resulted in systolic dyssynchrony with preserved diastolic synchrony in pediatric patients following catheter ablation for treatment of supraventricular tachycardia. Our results suggest that systolic and diastolic dyssynchrony are not tightly coupled and may develop through separate mechanisms.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2007.01079.x","type":"journal-article","created":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T07:58:28Z","timestamp":1202284708000},"page":"483-488","source":"Crossref","is-referenced-by-count":16,"title":["Acute Pacing\u2010Induced Dyssynchronous Activation of the Left Ventricle Creates Systolic Dyssynchrony with Preserved Diastolic Synchrony"],"prefix":"10.1111","volume":"19","author":[{"given":"BRANDON K.","family":"FORNWALT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROSE M.","family":"CUMMINGS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKESHI","family":"ARITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANA 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