{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T06:10:50Z","timestamp":1697091050528},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T00:00:00Z","timestamp":1202860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p> <jats:italic>Objectives:<\/jats:italic> We compared, in patients with sick sinus syndrome, the effects of various pacing modes on baroreceptor (BR)\u2010stroke volume (SV) reflex sensitivity, a method we have closely correlated with BR\u2010heart rate (HR) reflex sensitivity.<\/jats:p><jats:p> <jats:italic>Background:<\/jats:italic> Impaired autonomic nervous function, such as decreased BR\u2010HR reflex sensitivity, predicts sudden cardiac death. However, in patients with sick sinus syndrome, the effects of various pacing modes on autonomic function are unknown, since chronotropic incompetence precludes its evaluation by measurements of BR\u2010HR reflex sensitivity.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> We studied 12 recipients of dual\u2010chamber pacemakers with sick sinus syndrome (mean age = 73 \u00b1 8 years; 8 men). Beat\u2010by\u2010beat blood pressure (BP) and SV were measured during 5\u2010minute runs of AAI, DDD, and VVI pacing, and spectrally analyzed to assess BR\u2010SV reflex sensitivity.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Systolic BP was significantly lower (P &lt; 0.01) during VVI (109 \u00b1 24 mmHg) than during DDD (124 \u00b1 22 mmHg) or AAI (125 \u00b1 41 mmHg) pacing. SV was significantly smaller during VVI (36 \u00b1 23 mL) than during DDD (49 \u00b1 31 mL) pacing (P &lt; 0.05). BR\u2010SV reflex sensitivity was significantly lower (P &lt; 0.05) during VVI (9.3 \u00b1 5.7% per mmHg) than during DDD (15.0 \u00b1 6.5% per mmHg) or AAI (15.5 \u00b1 6.2% per mmHg) pacing.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> BR\u2010SV reflex sensitivity was significantly lower during VVI than during AAI or DDD pacing. Atrioventricular synchrony plays an important role in the preservation of BR\u2010SV reflex sensitivity in pacemaker recipients.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2008.01109.x","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T18:06:49Z","timestamp":1202926009000},"page":"702-707","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Pacing Modes on Cardiac Baroreflex Function in Permanently Paced Patients with Sinus Node 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