{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:54:08Z","timestamp":1771008848215,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,5,2]],"date-time":"2008-05-02T00:00:00Z","timestamp":1209686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p> <jats:bold>\n            <jats:italic>Background:<\/jats:italic>\n          <\/jats:bold> The mechanistic and clinical significance of complex fractionated atrial electrograms (CFAE) in the coronary sinus (CS) has been unclear.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods and Results:<\/jats:italic>\n          <\/jats:bold> Antral pulmonary vein isolation (APVI) was performed in 77 patients with paroxysmal (32) or persistent AF (45). CS electrograms recorded for 60 seconds before and after APVI were analyzed in the time\u2010 and frequency\u2010domains. Dominant frequency (DF), complexity index (CI: change in polarity of depolarization), and fractionation index (FI: change in direction of depolarization slope) were determined. Before APVI, there was no difference in DF, CI, or FI between paroxysmal and persistent AF. APVI resulted in a significant decrease in DF, CI, and FI in all patients. Baseline CI (43 \u00b1 13\/s vs 54 \u00b1 14\/s, P = 0.03) and FI (64 \u00b1 23\/s vs 87 \u00b1 30\/s, P = 0.02) were lower in patients with paroxysmal AF who had AF terminated by ablation than who did not. At 10 \u00b1 2 months, 69% of patients with paroxysmal AF and 49% of patients with persistent AF were free from AF after single ablation. Baseline CI was higher among patients with paroxysmal AF who had AF after APVI (56 \u00b1 20\/s vs 44 \u00b1 10\/s, P = 0.03). In patients with persistent AF, there was a larger decrease in DF after APVI among patients who remained free from AF (13 \u00b1 11% vs 7 \u00b1 9%, P &lt; 0.05).<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusions:<\/jats:italic>\n          <\/jats:bold> Complexity of CS electrograms may reflect drivers of AF that perpetuate paroxysmal AF after APVI. In persistent AF, the extent to which APVI decreases DF in the CS correlates with efficacy, suggesting that DF identifies patients who may require additional ablation beyond APVI.<\/jats:p>","DOI":"10.1111\/j.1540-8167.2008.01175.x","type":"journal-article","created":{"date-parts":[[2008,5,5]],"date-time":"2008-05-05T04:04:42Z","timestamp":1209960282000},"page":"1017-1023","source":"Crossref","is-referenced-by-count":30,"title":["Complex Electrograms Within the Coronary Sinus: Time\u2010 and Frequency\u2010Domain Characteristics, Effects of Antral Pulmonary Vein Isolation, and Relationship to Clinical Outcome in Patients with Paroxysmal and Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"19","author":[{"given":"KENTARO","family":"YOSHIDA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAGNUS","family":"ULFARSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"TADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMAN","family":"CHUGH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERIC","family":"GOOD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL","family":"KUHNE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"CRAWFORD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN F.","family":"SARRAZIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAGIB","family":"CHALFOUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DARRYL","family":"WELLS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRIT","family":"JONGNARANGSIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"JR","given":"FRANK","family":"PELOSI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANK","family":"BOGUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRED","family":"MORADY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HAKAN","family":"ORAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1996.tb03269.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.054"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.601898"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.691386"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.575340"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.6.647"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.04.053"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.641225"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.03136.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00612-5"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1619"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01189.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00211.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01028.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00863.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00554-5"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130645.95357.97"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00645.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.03222.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00764.x"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1540-8167.2008.01175.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1540-8167.2008.01175.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:29:33Z","timestamp":1696966173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1540-8167.2008.01175.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,20]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1111\/j.1540-8167.2008.01175.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1540-8167.2008.01175.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,20]]}}}